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Louis J. Muglia, M.D., Ph.D. [ contact information ]
Alumni Endowed Professor of Pediatrics; Professor of Molecular Biology and Pharmacology, Director, Center for Preterm Birth Research;
Unit Leader Developmental Biology and Genetics;
Divisional Director Division of Pediatric Endocrinology and Diabetes
Louis J. Muglia, M.D., Ph.D. received
his M.D. and Ph.D. degrees from the University of
Chicago Pritzker School of Medicine as a member of the
Medical Scientist Training Program, and went on to
complete his pediatric residency and pediatric
endocrinology fellowship at Children's Hospital, Boston.
Dr. Muglia joined the Division of Pediatric
Endocrinology and Diabetes at Washington University in
1996, and is board certified in Pediatrics and Pediatric
Endocrinology. He is a member of both the Endocrine
Society and the Lawson Wilkins Pediatric Endocrine
Society. His clinical interests include a wide range of
endocrine disorders, with special emphasis on pituitary
and adrenal diseases.
The research efforts of our laboratory center on defining the role of neuropeptides
produced by the hypothalamus in perinatal adaptation, reproduction,
behavior, and immune function. We have a long-standing interest
in the control of the mammalian stress response and the critical
function for glucocorticoids in maintenance of physiological homeostasis.
To this end, we have generated and utilized transgenic, conventional
knockout, and most recently, conditional knockout mice to determine
the role of corticotropin-releasing hormone, oxytocin, adenylyl
cyclase type VIII, and the glucocorticoid receptor in the adrenal
and behavioral responses to stress. Of ongoing interest is defining
the mechanisms by which the immune system and hypothalamic-pituitary
adrenal axis interact during inflammatory stress and thymocyte selection.
The second area of major interest in our laboratory is in the elucidation
of the mechanism imparting normal term labor, and how this mechanism
malfunctions to result in preterm labor. To define the mechanism
of parturition control, we have continued to use the mouse as our
system of choice because of the in vivo genetic analysis
it allows. Our initial parturition studies systematically determined
the importance of oxytocin and prostaglandins for term labor, two
pathways that had been shown by pharmacological means to promote
labor. Our ongoing studies seek to elucidate novel molecules in
parturition control using gene microarrays and genetic linkage analysis.
Dr. Muglia received the prestigious Young Investigator's
Award from the Society for Pediatric Research in 1999
and was elected to membership in
the American Society for Clinical Investigation in 2003.
Selected Publications
Brewer JA, Khor B, Vogt SK, Muglia LM, Fujiwara H, Haegele KE, Sleckman BP,
Muglia LJ:
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation
Nat Med
2003;
9: 1318-1322.
pubmed
Bethin KE, Nagai Y, Sladek R, Asada M, Sadovsky Y, Hudson TJ,
Muglia LJ:
Microarray analysis of uterine gene expression in mouse and human
pregnancy.
Mol Endocrinol
2003;
17: 1454-1469.
pubmed
Maas JW Jr, Vogt SK, Chan GCK, Pineda VV, Storm DR, Muglia LJ:
Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity
J Neurosci
2005;
25: 4118-4126.
pubmed
Boyle MP, Brewer JA, Funatsu M, Wozniak DF, Tsien JZ, Izumi Y, Muglia LJ:
Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior Proc.
Natl Acad Sci USA
2005;
102: 473-478.
pubmed
Maas JW Jr, Indacochea RA, Muglia LM, Tran TT, Vogt SK, West T, Benz A, Shute AA, Holtzman DM, Mennerick S, Olney JW,
Muglia LJ:
Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain
J Neurosci
2005;
25: 2376-2385 .
pubmed
Kistka ZA, Palomar L, Lee KA, Boslaugh SE, Wangler MF, Cole FS, Debaun MR,
Muglia LJ:
Racial disparity in the frequency of recurrence of preterm birth
Am J Obstet Gynecol
2007;
196:131.e1-131.e6.
pubmed
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