The lab primarily studies the interactions of
pathogenic Gram-negative bacteria with their hosts. In
particular, we utilize tissue culture models and mouse models to
investigate the modulation of host immune responses by pathogens,
and to determine the mechanisms by which these bacteria present
specific virulence factors on their surfaces. Currently, we are
studying the molecular mechanisms by which conserved periplasmic
chaperones, such as SurA and Skp, contribute to the assembly and
presentation of surface virulence factors by Gram-negative
pathogens. In addition, we are using cultured bladder epithelial
cells and the murine model of cystitis to investigate the ability
of uropathogenic E. coli to downregulate host inflammatory
cytokine production. Our goal is to discover novel targets for
interventions that will prevent and treat Gram-negative infections
of the urinary tract, gastrointestinal tract, and central nervous
system.
Our lab is part of the Pathobiology Research Unit in the
Department of Pediatrics. It is located on the 6th floor of the
McDonnell Pediatric Research Building.
Contact Information
660 S. Euclid Ave. Campus Box 8208 St. Louis, MO 63110 (314) 286-2710 (314) 286-2874 lab (314) 286-2895 fax
SCHOOL OF MEDICINE
