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Publications

Selected Publications

1. Hruz PW and Mueckler M: Cysteine-Scanning Mutagenesis of Transmembrane Segment 7 of the GLUT1 Glucose Transporter J. Biol. Chem. 1999; 274: 36176-36181 [ pubmed ]

2. Murata H, Hruz, PW, and Mueckler M: The Mechanism of Insulin Resistance Caused by HIV Protease Inhibitor Therapy J. Biol. Chem. 2000; 275: 20251-20254 [ pubmed ]

3. Murata H, Hruz PW and Mueckler, M: Indinavir inhibits the glucose transporter GLUT4 at physiologic concentrations AIDS 2002; 16(6):859-863 [ pubmed ]

4. Hruz PW, Murata H, Qiu H, and Mueckler M: Indinavir induces acute and reversible peripheral insulin resistance in rats. Diabetes 2002; 51: 937-942 [ pubmed ]

5. Koster JC, Remidi M.S., Qiu H, Nichols C and Hruz PW: HIV Protease Inhibitors Acutely Impair Glucose-Stimulated Insulin Release Diabetes 2003: 52(7): 1695-1700 [ pubmed ]

6. Hertel J, Struthers H, Baird Horj C, and Hruz PW: A Structural Basis for the Acute Effects of HIV Protease Inhibitors on GLUT4 Intrinsic Activity J Biol Chem. 2004;279(53):55147-52 [ pubmed ]

7. Yan, Q and Hruz, PW: Direct Comparison of the Acute In Vivo Effects of HIV Protease Inhibitors on Peripheral Glucose Disposal. J. Acquired Immune Defic. Syndr., 40(4): 398-403,2005. [ pubmed ]

Selected Reviews

1. Hruz PW, Murata H and Mueckler M: Adverse metabolic consequences of HIV protease inhibitor therapy: the search for a central mechanism Am. J. Physiol. 2001; 280: E549-E553 [ pubmed ]

2. Hruz PW and Mueckler M: Structural Analysis of the GLUT1 Facilitative Glucose Transporter Mol. Membr. Biol, 2001; 18(3): 183-193 [ pubmed ]

3. Hruz, PW : Molecular Mechanisms for Altered Glucose Homeostasis in HIV infection. Am. J. Infectious Dis. 2006; 2(3):187-192 [ pubmed ]