Research | HRUZ LAB
Our research efforts are directed toward
understanding facilitative glucose transport as it relates to
normal and disordered glucose homeostasis. A primary effort in
our laboratory is the determination of structure/function
relationships within the facilitative glucose transport proteins
(GLUTs). We are using state of the art chemical and biophysical
approaches to the determination of tertiary and quaternary
structures of the human erythrocyte glucose transporter GLUT1 and
the insulin responsive glucose transporter GLUT4.
In addition, we are also investigating the in vitro and in vivo
effects of HIV protease inhibitors (PIs)on GLUT function. The
goal of this research is to identify the molecular mechanisms that
lead HIV infected patients receiving PIs to develop insulin
resistance. 
Contact Information
Paul W Hruz, M.D., Ph.D.
Assistant Professor
Division of Endocrinology and Metabolism
Department of Pediatrics
Washington University School of Medicine
Campus Box 8208
McDonnell Pediatric Research Building
660 South Euclid Avenue
St. Louis, MO 63110 Office: 314-286-2797
Lab: 314-286-2794
FAX: 314-286-2892
e-mail:
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SCHOOL OF MEDICINE
