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Research | GRADY LAB

Our lab works on several proteins that have been identified as part of a large complex called the dystrophin-glycoprotein complex or dgc. The dgc is a membrane associated complex found in a variety of tissues, including the cns and striated muscle. Mutations within the muscle dgc often lead to muscular dystrophy both in mice and humans. One dgc protein in particular has been a recent focus of our lab, alpha-dystrobrevin (adb). We created knockout adb mice and found that not only do they have a muscular dystrophy they also have abnormalities at their neuromuscular junctions. We are currently trying to understand how adb promotes both muscle and synaptic stability. Techniques used include knockout and transgenic mice work (and all the requsite molecular biology) and a lot of immunohistochemistry. We are also pursuing other proteins that may interact with adb.

Contact Information

Mark Grady
One Children's Place
St Louis mo
63105
314-454-6095