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Hematology and Oncology | Fellowship Program




A photograph of one of our fellows.

Introduction

The division has a nationally recognized fellowship program designed to train specialist pediatricians seeking a career in academic pediatric hematology/oncology. Since our faculty has considerable strength in clinical and basic investigation, the program is well suited to candidates interested in both tracks. The program strives to not only make the trainee highly skilled in clinical care, but also capable of designing and performing sophisticated biomedical investigation that focuses on understanding and treating the childhood diseases as broadly defined by our specialty.

In order to train physicians appropriately for careers in this field, the fellowship lasts "three-plus" years. The first-year fellow has strictly clinical responsibilities with every third week on call from home. In addition to six months as supervisor of the in-house clinical service, the fellow rotates on electives in laboratories such as coagulation/blood bank, HLA lab, cyogenetics, molecular diagnostics and clinical services including radiation therapy, pathology, pheresis, adult hematology and bone marrow transplant. This broad curriculum provides a strong foundation for the fellow ensuring that he or she is well equipped with an extensive and sophisticated fund of knowledge.

After the first year, the fellow begins an individualized program of clinical or basic science investigation mentored by a faculty investigator at the School of Medicine. During this period, the trainee is expected to develop the knowledge, thought processes and laboratory skills necessary to develop into an independent, competitive investigator in today's scientific community. In order to focus on his or her investigation, the fellow's clinical responsibilities are limited to attending one clinic day each week and two clinical conferences.

The program has a long history of developing successful physician investigators. Our fellows have published numerous articles in highly competitive areas of biomedical research, and they continue to maintain a history of success in acquiring extramural funding support. Thus, fellows who graduate from our program can be confident that they will meet the challenges they will face as they advance through their academic careers.


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Current Fellows

Jeffrey Bednarski, M.D.  c

  • M.D. – University of Michigan, Ann Arbor, Michigan 2003
  • Residency – St. Louis Children's Hospital, St. Louis, Missouri 2003 - 2006
  • Research: DNA repair and lymphocyte development

Todd Druley, M.D.  c

  • M.D., University of Illinois, Chicago, IL 2002
  • Ph.D., University of Illinois, Chicago, IL 2002
  • Residency – St. Louis Children's Hospital, St. Louis, Missouri 2002-2005
  • Research: the relationship of p53 mutation with malignant gliomas

Melissa J. Frei-Jones, M.D.  c

  • M.D., University of Texas Southwestern Medical School, Dallas Texas 2002
  • Residency – Children's Medical Center, Dallas Texas 2002-2005
  • Research: strategies of pain control in sickle cell disease

Julie Kanter, M.D.  c

  • M.D. – Tulane University, New Orleans, Louisiana 2003
  • Residency – University of Colorado, Denver, Colorado 2003 - 2006
  • Research: nitric oxide signaling as it relates to platelet activation and aggregation

Ghada M. Kunter, M.D.  c

  • University of Mosul College of Medicine, Mosul, Iraq 1988
  • Residency – University of Kansas, Wichita, Kansas 2000-2004
  • Research: investigation of myelopoeisis and trafficking

Sharon McDonald, M.D.  c

  • M.D. – University of Mississippi, Jackson, Mississippi 2004
  • Residency – University of Arkansas/Little Rock Children's Hospital, Arkansas 2004-2007
  • Currently proceeding through the clinical first year rotations

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Awards and Grants From Current and Past Fellows

  1. National Research Service Award, NCI, 1991
  2. Functional Domains of NGF-IA, National Research Service Award, NIH, 1991
  3. Regulation of Lens Gap Junctions, National Research Service Award, NIH, 1991
  4. National Research Service Award, NIH, 1992
  5. Howard Hughes Medical Institute, Postdoctoral Fellowship, 1993
  6. American Cancer Society Post Doctoral Fellowship, 1993
  7. Pfizer Inc. Postdoctoral Fellowship, 1993
  8. American Association for Cancer Research, 1992
  9. American Heart Association Missouri Affiliate Fellowship, 1994
  10. Pediatric Medical Oncology Physician Scientist Award NIH, 1992
  11. Leukemia Society Fellowship Award, 1993
  12. Clinical Investigator Development Award NIH, 1994
  13. American Cancer Society Clinical Oncology Fellowship, 1994
  14. Pediatric Oncology Physician Scientist Award, 1994
  15. Robert Steel Foundation Research Fellowship, 1994
  16. Howard Hughes Medical Institute, Postdoctoral Research Fellowship for Physicians, 1995
  17. Clinical Investigator Development Award NIH, 1995
  18. Pediatric Medical Oncology Physician scientist Award, NIH, 1995
  19. American Cancer Society Clinical Oncology Fellowship, 1995
  20. Children's Brittle Bone foundation Fellowship, 1996
  21. American Heart Association Missouri Affiliate Fellowship, 1996
  22. Cure Foundation Fellowship, 1996
  23. American Society for Hematology, Fellow Award, 1997
  24. American Heart Association Missouri Affiliate Fellowship, 1997
  25. American Medical Association Education and Research Foundation, Florence A. Carter Fellowship Program in Leukemia Research, 1997
  26. National Research Service Award, NIH, 1997
  27. Children's Cancer Research Fund, 1997
  28. Minorities in Medical Oncology Award NIH, 1998
  29. Pediatric Scientist Development Training Program, 1999
  30. American Society for Hematology, Fellow Award, 2000
  31. American Heart Association Missouri Affiliate Fellowship, 2003
  32. Amgen Hematology and Oncology Fellowship Program, 2004
  33. American Cancer Society Institutional Research Grant, 2004
  34. Hope Street Kids Grant and Fellowship Awards, 2007
  35. ASCO Foundation Young Investigator’s Award (YIA), 2007
  36. Children's Discovery Institute; McDonnell Pediatric Cancer Center Fellowship, 2007

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Selected References From Current and Past Fellows

1.     Blunt AG, Lawshe A, Cunningham ML, et al: Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands. Journal of Biological Chemistry 272:3733-8, 1997.

2.     Boudreaux JM, Towler DA: Synergistic induction of osteocalcin gene expression: identification of a bipartite element conferring fibroblast growth factor 2 and cyclic AMP responsiveness in the rat osteocalcin promoter. Journal of Biological Chemistry 271:7508-15, 1996.

3.     Brandt JM, Djouadi F, Kelly DP: Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. Journal of Biological Chemistry 273:23786-92, 1998.

4.     Crawford DF, Piwnica-Worms H: The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators. Journal of Biological Chemistry 276:37166-37177, 2001.

5.     DeBaun MR, Glauser TA, Siegel M, et al: Noninvasive central nervous system imaging in sickle cell anemia. A preliminary study comparing transcranial Doppler with magnetic resonance angiography. Journal of Pediatric Hematology/Oncology 17:29-33, 1995.

6.     DeBaun MR, Brown M, Kessler L: Screening for Wilms' tumor in children with high-risk congenital syndromes: considerations for an intervention trial. Medical & Pediatric Oncology 27:415-21, 1996.

7.     Djouadi F, Brandt JM, Weinheimer CJ, et al: The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism. Prostaglandins Leukotrienes & Essential Fatty Acids 60:339-43, 1999.

8.     Frei-Jones MJ BA, Rogers ZR,  Buchanan GR. Vaso-occlusive episodes in older children with sickle cell disease: emergency department management and pain assessment. J Peds 2007; In press.

9.     Gauvain KM, McKinstry RC, Mukherjee P, et al: Evaluating pediatric brain tumor cellularity with diffusion-tensor imaging. AJR. American Journal of Roentgenology 177:449-54, 2001.

10.   Gomperts BN, Gong-Cooper X, Hackett BP: Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. Journal of Cell Science 117:1329-37, 1329.

11.   Grossman WJ, Verbsky JW, Barchet W, et al: Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21:589-601, 2004.

12.   Grossman WJ, Verbsky JW, Tollefsen BL, et al: Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104:2840-8, 2004.

13.   Hanson R.D., Hess JL, Yu BD, et al: Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proceedings of the National Academy of Sciences of the United States of America 96:14372-7, 1999.

14.   Herron S, Bacak SJ, King A, et al: Inadequate recognition of education resources required for high-risk students with sickle cell disease. Archives of Pediatrics & Adolescent Medicine. 157:104, 2003.

15.   Hulbert ML. Scothorn DJ. Panepinto JA. Scott JP. Buchanan GR. Sarnaik S. Fallon R. Chu JY. Wang W. Casella JF. Resar L. Berman B. Adamkiewicz T. Hsu LL. Smith-Whitley K. Mahoney D. Woods G. Watanabe M. DeBaun MR. Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia Journal of Pediatrics. 149(5):710-2, 2006 Nov.

16.   Kelly ME, Chan AC: Regulation of B cell function by linker proteins. Current Opinion in Immunology 12:267-75, 2000.

17.   King AA, Tang S, Ferguson KL, et al: An education program to increase teacher knowledge about sickle cell disease. Journal of School Health 75:11-4, 2005.

18.   Link DC, Kunter G, Kasai Y, Zhao Y, Miner T, McLellan MD, Ries RE, Kapur D, Nagarajan R, Dale DC, Bolyard AA, Boxer LA, Welte K, Zeidler C, Donadieu J, Bellannι-Chantelot C, Vardiman JW, Caligiuri MA, Bloomfield CA, DiPersio JF, Tomasson MH, Graubert TA, Westervelt P, Watson M, Shannon W, Baty J, Mardis ER, Wilson RK, and Ley TJ. Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia.  Blood, Sep 2007; 110: 1648 - 1655.

19.   Luchtman-Jones L, Broze GJ: The current status of coagulation. Annals of Medicine 27:47-52, 1995.

20.   Mascotti DP, Rup D, Thach RE: Regulation of iron metabolism: translational effects mediated by iron, heme, and cytokines. Annual Review of Nutrition 15:239-61, 1995.

21.   Mascotti DP, Goessling LS, Rup D, et al: Effects of the ferritin open reading frame on translational induction by iron. Progress in Nucleic Acid Research & Molecular Biology 55:121-34, 1996.

22.   McLemore ML, Grewal S, Liu F, et al: STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity 14:193-204, 2001.

23.   Newberry EP, Boudreaux JM, Towler DA: The rat osteocalcin fibroblast growth factor (FGF)-responsive element: an okadaic acid-sensitive, FGF-selective transcriptional response motif. Molecular Endocrinology 10:1029-40, 1996.

24.   Rao A. Kamani N. Filipovich A. Lee SM. Davies SM. Dalal J. Shenoy S. Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning. Blood. 109(1):383-5, 2007 Jan 1.

25.   Richards MK, Liu F, Iwasaki H, et al: Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway.Blood 102:3562-8, 2003.

26.   Saylors RL, 3rd, Sidransky D, Friedman HS, et al: Infrequent p53 gene mutations in medulloblastomas. Cancer Research 51:4721-3, 1991.

27.   Schaefer A, Jasinski M, Bessler M: High-dose cyclophosphamide does not eradicate paroxysmal nocturnal haemoglobinuria haematopoiesis in mice carrying a Piga gene mutation. British Journal of Haematology. 120:903-6, 2003.

28.   Wasson JC, Saylors RL, 3rd, Zeltzer P, et al: Oncogene amplification in pediatric brain tumors. Cancer Research 50:2987-90, 1990.

29.   Yamaguchi Y, Heiny ME, Shimizu N, et al: Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat. Biochemical Journal 301:1-4, 1994.

30.   Yamaguchi Y, Heiny ME, Suzuki M, et al: Biochemical characterization and intracellular localization of the Menkes disease protein. Proceedings of the National Academy of Sciences of the United States of America 93:14030-5, 1996.

31.   Yang E, Zha J, Jockel J, et al: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285-91, 1995.

32.   Yu BD, Hanson R.D., Hess JL, et al: MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proceedings of the National Academy of Sciences of the United States of America 95:10632-6, 1998.

33.   Zha J, Harada H, Yang E, et al: Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619-28, 1996.


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Contact

Robert J. Hayashi, M.D.
C/O Peg Greco Schneider, Fellowship Administrator
Division of Hematology/Oncology
Department of Pediatrics
Washington University School of Medicine
660 S. Euclid Ave. Box 8116
St. Louis, MO 63110
(314) 454-4327 (Voice)
(314) 454-4283 (Fax)


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