Gregory A. Storch, M.D. [ contact information ]
Ruth L. Siteman Professor of Pediatrics;
Co-director Clinical Retrovirus Lab;
Director Division of Pediatric Laboratory Medicine;
Director Clinical Virology Lab;
Director Division of Infectious Diseases;
Director Bacteriology Laboratory;
Director Molecular Virology Laboratory
Dr. Storch's investigative activities involve the rapid diagnosis of
infections. The infectious agents of choice are those for which
existing methods are inadequate, either because the agent cannot be
cultivated or because current diagnostic methods are too slow or
insufficiently sensitive. The emphasis is on viral and other
unconventional agents and on infections at body sites such as the
central nervous system, the eye and the developing fetus, for which
PCR is well suited because of its sensitivity and small specimen
volume requirement.
Dr. Storch's approach is to develop PCR assays for several
infectious agents that produce related clinical syndromes in a
specific patient population and to use those PCR assays as panels to
define the spectrum of disease attributable to each of the agents.
PCR assays that have been developed to date include assays for all
human herpes viruses, parvovirus B19, JC and BK viruses, HIV,
enteroviruses, Ehrlichia spp, Rickettsia rickettsiae, Bartonella
species, Bordetella pertussis, and Toxoplasma gondii. Areas of
ongoing or future development include assays for respiratory viruses
and studies employing quantitative and real-time PCR.
These assays have been or will be used to investigate the following
clinical syndromes: central nervous system infection in patients
with AIDS (CMV, EBV, JC virus, T. gondii), systemic infection in
solid organ transplant recipients (CMV, EBV, HHV-6), central nervous
system infections in normal individuals (HSV, VZV, EBV,
enterovirus), retinitis in immunocompromised patients (CMV, VZV,
HSV), congenital infection (Parvovirus B19, T. gondii, CMV), and
tick-borne infections (Ehrlichia and Rickettsia). In each case,
appropriate collaborations are in place or will be established with
clinicians caring for the relevant patient group, and comparison
will be made to diagnostic testing using conventional methods,
carried out in the St. Louis Children's Hospital Diagnostic
Microbiology Laboratory.
Education
- A.B., Harvard University, 1969
- M.D., New York University Medical School, 1973
Training
- Intern and Resident in Internal Medicine, Jewish Hospital
of St. Louis, Washington University School of Medicine, St. Louis, Mo., 1973-1976
- Epidemic Intelligence Service Office, Centers for Disease Control,
Atlanta, GA (assigned to Louisiana Department of Health and Human Resources,
New Orleans, La.), 1976-1978
- Clinical and Research Fellow in Infectious Diseases, Washington
University School of Medicine, St. Louis, Mo., 1978-1998
Licensure and Board Certification
- Missouri, 1975
- National Board of Medical Examiners
- American Board of Internal Medicine, 1976
- American Board of Internal Medicine, Subspecialty of Infectious Diseases, 1980
Selected Publications
Brennan DC, Garlock KA, Singer GG, Schnitzler, MA,
Lippmann JB, Buller RS, Gaudreault-Keener M, Lowell JA,
Shenoy S, Howard TK, Storch GA:
Prophylactic oral
ganciclovir compared to deferred therapy for control of
cytomegalovirus-disease in renal transplant recipients.
Transplantation
1997;
64:1843-1846.
Tebas P, Nease RF, Storch GA:
Use of the polymerase
chain reaction in the diagnosis of herpes simplex
encephalitis.
Am J, Med
1998;
105:287-295.
Roberts TC, Brennan CD, Buller RS, Gaudreault-Keener M,
Schnitzler MA, Sternhell KE, Garlock KA, Singer GG,
Storch GA:
Quantitative PCR to predict occurrence of
symptomatic cytomegalovirus (CMV) infection and assess
response to ganciclovir therapy in renal transplant
recipients.
J Infect Dis
1998;
178:626-635.
Kruger RM, Shannon WD, Arens MQ, Lynch JP, Storch GA,
Trulock EP:
The impact of ganciclovir-resistant
cytomegalovirus infection after lung transplantation.
Transplantation
1999;
68:1272-1279.
Buller RS, Arens M Hmiel SP, Paddock CD, Sumner JW,
Rikihisa Y, Unver A, Gaudreault-Keener M, Manian FA,
Liddell AM, Schmulewitz N, Storch GA:
Ehrlichia ewingii,
a newly recognized agent of human ehrlichiosis.
N Engl J Med
1999;
341:148-155.
Storch GA:
Medical Microbiology: Diagnostic virology.
Clin Infect Dis
2000;
31:739-751.
Storch GA
(Eds. Knipe G, Howley P, Griffin D, Lamb R,
Martin M, Straus S):
Diagnostic Virology.
in
Fields Virology
;
Lippincott Williams &
Wilkins, Philadelphia, Pa., (in press).
Storch GA (ed):
.
Essentials of Diagnostic
Virology
1999;
Churchill-Livingstone, New York, NY.
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