Associate Professor of Pediatrics; Attending Physician in Hematology/Oncology and General Pediatrics; Director Pediatric Bone Marrow Transplant Program

• Patient Oriented Research
• Hematology and Oncology

Dr. Shenoy's research interests are focused on transplantation biology and the immunologic mechanisms of graft rejection, and graft versus host disease (GVHD), and immune reconstitution following bone marrow transplantation (BMT). Another area of investigation pursued by Dr. Shenoy is the mechanism of T cell deletion and the role of Fas-fas ligand in GVHD and autoimmune disease.

Dr. Shenoy's clinical research is focused on developing safe and effective non-myeloablative conditioning regimen in stem cell transplantation, especially as it relates to metabolic and non-malignant disorders.

Education

• M.B.B.S., Kasturba Medical College, Mysore University, 1981
• Doctor of Medicine in Pediatrics, Kasturba Medical College, Manipal, Mangalore University, 1985

Training

• Residency in General Pediatrics, LSUMC and Charity Hospital, New Orleans,
  1989-1991
• Fellow in Pediatric Hematology/Oncology, Washington University School of Medicine, 1992
• Fellow in Pediatric Hematology/Oncology, Washington University School of Medicine, 1992-1995

Licensure and Board Certification

• Missouri License, 1994
• Pediatric Board Certified, 1991; recertified 1999
• Pediatric Hematology and Oncology, 1996; recertified 2002

Honors

• National Institutes of Health, Mentored Clinical Scientist Development Award,
  1997-2002
• American Cancer Society, Institutional Research Grant, 1997-1998
• ASHI Scholar, 2001

Selected Publications

1. Shenoy S, Mohanakumar T, Todd G, Westhoff W, Dunnigan K, Adkins DR, Brown RA, DiPersio JF: Immune reconstitution following allogeneic peripheral blood stem cell transplants. Bone Marrow Transplantation 1999; 23(4):335-346.

2. Shenoy S, Arnold S, Chatila T: Response to steroids in autism secondary to autoimmune lymphoproliferative syndrome. J Peds 2000; 136 (5): 682-7.

3. Adkins D, Goodnough LT, Shenoy S, Brown R, Moellering J, Khoury H, Vij R, DiPersio J: Effect of leukocyte compatibility on neutrophil increment after transfusion of G-CSF mobilized prophylactic granulocyte transfusions and on clinical outcomes after stem cell transplant. Blood 2000; 95: 3605-12.

4. Shenoy S, Mohanakumar T, Chatila T, Tersak J, Duffy B, Wang R, Russell JH: Defective apoptosis in lymphocytes and the role of IL-2 in autoimmune hematologic cytopenias. Clinical Immunology 2001; 99 (2):266-275.

5. Goral J, Shenoy S, Mohanakumar T, Clancy J Jr.: Antibodies to 70 kD and 90 kD heat shock proteins are associated with graft-versus-host disease in peripheral blood stem cell transplant recipients. Clin Exp Immunol 2002; 127 (3):553-9.