Instructor of Pediatrics

• Allergy and Pulmonary Medicine
• Cystic Fibrosis Center

Dr. Patel is a member of the Division of Allergy and Pulmonary Medicine. He received his undergraduate degree in biology from the University of Illinois at Urbana-Champaign, and his medical degree from Rush University in Chicago, IL. Dr. Patel was an intern and resident in pediatrics at the University Hospital and Medical Center at Stony Brook, New York. He was a pediatric pulmonology fellow at Washington University before joining the faculty in 2005. He is board certified in Pediatrics and in Pediatric Pulmonology. He is a member of several organizations including the American Thoracic Society.

Research

My primary research goal is to better define the immune and signal transduction basis for the two major components of chronic airway disease: goblet cell metaplasia and airway hyperreactivity. This includes a desire to understand the underlying genetic and environmental factors that initiate and perpetuate these disease phenotype features. I am particularly focused on the early stages of asthma in childhood and the role of viral infection in that setting.

Working the laboratory of Dr. Michael Holtzman, M.D. in the division of Pulmonary/Critical Care Medicine in the Department of Internal Medicine, we have established several new insights into the pathogenesis of complex airway diseases. In particular, we have developed an experimental model for segregating airway disease traits induced by viral infection, and are thereby defining independent genetic susceptibilities for developing the individual traits of mucous cell metaplasia versus airway hyperreactivity. Further work in this area has led to the evaluation of several members of the calcium-activated chloride channel (CLCA) gene family as genes involved in the development of mucous cell metaplasia and mucus hypersecretion; features of human asthma. In the future, we hope that these explorations will lead to improved therapies for asthma and other lung diseases.

Education

• B.S., University of Illinois at Urbana-Champaign, 1995
• M.D., Rush University Medical College, Chicago, IL, 1999

Training

• Intern in Pediatrics, University Hospital and Medical Center at Stony Brook, NY, 1999-2000
• Resident in Pediatrics, University Hospital and Medical Center at Stony Brook, NY, 2000-2002
• Fellow in Pulmonary Medicine, St. Louis Children's Hospital, 2002-2005

Academic Appointments

• Instructor in Pediatrics, Washington University School of Medicine, 2005-present

Licensure and Board Certification

• Missouri, 2005-present
• American Board of Pediatrics, General Pediatrics, 2002-2009
• American Board of Pediatrics, Pediatric Pulmonology, 2006-2013

Honors

• National Institutes of Health Summer Research Fellowship, 1996
• National Institutes of Health Summer Research Fellowship, 1997
• Selected delegate, American Academy of Allergy, Asthma, and Immunology conference, 2000
• Selected delegate, GSK Pulmonary Fellows Symposium, 2004
• Scholar of the Child Health Research Center of Excellence in Developmental Biology at the Washington University School of Medicine, 2006-2007

Selected Publications

1. Yang Y, Glover GH, van Gelderen P, Patel AC, Mattay VS, Frank JA, Duyn JH.: A comparison of fast MR scan techniques for cerebral activation studies at 1.5 tesla. Magn Reson Med. 1998; Jan;39(1):67-7.

2. Frank JA, Ostuni JL, Yang Y, Shiferaw Y, Patel A, Qin J, Mattay VS, Lewis BK, Levin RL, Duyn JH: Technical solution for an interactive functional MR imaging examination: application to a physiologic interview and the study of cerebral physiology.. Radiology 1999; Jan;210(1):260-8.

3. Tyner JW, Uchida O, Kajiwara N, Kim EY, Patel AC, O'Sullivan MP, Walter MJ, Schwendener RA, Cook DN, Danoff TM, Holtzman MJ: CCL5/CCR5 interaction provides anti-apoptotic signals for macrophage survival during viral infection.. Nat Med 2005; Nov;11(11):1180-7.

4. Tyner JW, Kim EY, Ide K, Pelletier MR, Roswit WT, Morton JD, Battaile JT, Patel AC, Patterson GA, Castro M, Spoor M.S., You Y, Brody SL, and Holtzman MJ. : Blocking airway mucous cell metaplasia by inhibiting EGFR anti-apoptosis and IL-13 transdifferentiation signals. . J. Clin. Invest 2006; 116: 309-21.

5. Patel AC, Morton JD, Kim EY, Alevy Y, Swanson S, Tucker J, Huang G, Agapov E, Phillips TE, Fuentes ME, Iglesias A, Aud D, Allard JD, Dabbagh K, Peltz G, Holtzman MJ.: Genetic segregation of airway disease traits despite redundancy of chloride channel calcium-activated (CLCA) family members. Physiol Genomics 2006; 25(3):502-13.