Assistant Professor of Pediatrics

• Endocrinology and Diabetes
• Patient Oriented Research

Rebecca Green, M.D., Ph.D. joined the faculty of endocrinology and diabetes (metabolism) in 2000. Dr. Green received her M.D. and Ph.D degrees from Washington University School of Medicine and went on to complete her pediatric residency and fellowship training at St. Louis Children's Hospital. She is board certified in Pediatrics and Pediatric Endocrinology. She is a member of The American Academy of Pediatrics, The American Diabetes Association, The Endocrine Society, The Lawson Wilkins Pediatric Endocrine Society, The American Society of Bone and Mineral Research and the International Bone and Mineral Research Society. Dr. Green's clinical interests extend to all areas of pediatric endocrinology and metabolism, with a particular interest in metabolic bone disease.

Dr. Green's research experience has included basic science work in a number of areas. These include:

• The regulation of intestinal development, including the role of thyroid hormone
• The regulation of long bone growth by fibroblast growth factors
• The regulation of gonad differentiation by fibroblast growth factors

She designed and completed a pilot study evaluating the use of a portable clinical analyzer in the home setting for children with diabetes insipidus, which was published in the Journal of Pediatrics. Her current research interests are clinical and include the evaluation, prevention and treatment of metabolic bone diseases in children, with a strong emphasis on bone disease caused by glucocorticoid therapy in children with chronic diseases.

Selected Publications

1. Green RP, Birkenmeier EH, Beamer WG, Maltais LJ, Gordon JI: The hypothyroid (hyt/hyt) mouse: A model system for studying the effects of thyroid hormone on developmental changes in gene expression. Proc. Natl. Acad. Sci. 1988; USA 85, 5592-5596.

2. Green RP, Cohn SM, Sacchettini JC, Jackson KE Gordon JI: The mouse intestinal fatty acid binding protein gene: Nucleotide sequence, pattern of developmental regulation and proposed structure of its protein product. DNA and Cell Biology 1992; 11, 31-41.

3. Hermiston ML, Green RP, Gordon JI: Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated. Proc. Natl. Acad. Sci. 1993; USA 90, 8866-8870.

4. McEwen DG, Green RP, Naski MC, Towler DA, Ornitz DM: Fibroblast Growth Factor Receptor 3 gene transcription is suppressed by cyclic adenosine 3',5'-monophophate: Identification of a chondrocyte regulatory element. J. Biol. Chem. 1999; 274, 30934-42.

5. Colvin JS, Green RP, Schmahl J, Capel B, Ornitz DM: Male-to-Female Sex Reversal in Mice Lacking Fibroblast Growth Factor 9: An essential role for FGF signaling in testicular embryogenesis. Cell 2001; 104, 875-889.

6. Green RP, Landt M: Home Sodium Monitoring in Diabetes Insipidus. Journal of Pediatrics 2002; 141: 618-24.