Instructor in Pediatrics; Associate Director Cystic Fibrosis Center

• Cystic Fibrosis Center
• Allergy and Pulmonary Medicine
• Pathobiology

Dr. Cannon is a member of the Division of Allergy and Pulmonary Medicine. She received her undergraduate degree in bioengineering from Texas A & M University, a Masters in electrical engineering from Worcester Polytechnic Institute, Worcester, MA, her medical degree from University of Texas Medical School, Houston, and her Ph.D. from University of Texas Graduate School of Biomedical Sciences, Houston. Dr. Cannon was an intern and resident in pediatrics at Children's Hospital in Boston. She was a fellow in Pediatric Pulmonology at Children's Hospital, Boston. She joined the faculty of Washington University in 2003. She is board certified in Pediatrics and Pediatric Pulmonology. She is a member of several organizations including the American Medical Association, the American Academy of Pediatrics, the American Physiological Society, the American Association for the Advancement of Science, and the American Thoracic Society.

Research

Our laboratory seeks to understand the pathobiology of host-bacterial interaction in the genesis of the pulmonary infections that plague cystic fibrosis (CF) patients. The protein defective in CF, the cystic fibrosis transmembrane regulator (CFTR), subserves numerous functions in respiratory epithelium including that of a sensor for bacteria that colonize the lungs of patients with CF. Using both in vitro and animal models of infection, we are studying the interaction of pathogenetic organisms with CFTR and the downstream pathways that are activated.

Education

• B.S., Texas A & M University, 1982
• M.S., Worcester Polytechnic Institute, 1985
• M.D., University of Texas Medical School, 1993
• Ph.D., University of Texas Graduate School of Biomedical Sciences, 1993

Training

• Intern in Pediatrics, Children's Hospital, Boston, 1993-1994
• Resident in Pediatrics, Children's Hospital, Boston, 1994-1996
• Fellow in Pulmonary Medicine, Children's Hospital, Boston, 1996-1999
• Research Fellow, Channing Laboratory, Brigham & Women's Hospital, 1998-1999

Licensure and Board Certification

• Massachusetts 1999
• Missouri, 2003
• American Board of Pediatrics, 1996
• Pediatric Pulmonology, 2000

Honors

• Welch Fellowship, University of Texas, 1978-1797
• Undergraduate Research Fellowship, University of Texas, 1980
• Alpha Eta Mu Beta, 1981-1982
• Undergraduate Research Fellowship, Texas A   M University, 1982
• Eta Kappa Nu, 1984-1985
• Outstanding Student in Pediatrics, University of Texas Medical School, 1993
• Walter S. Sterling Award of Academic Excellence, University of Texas Medical School, 1993

Selected Publications

1. Cannon CL, Basavappa S, Strange K.: Intracellular ionic strength regulates the volume sensitivity of a swelling-activated anion channel. Am J Physiol Cell Physiol 1998; 275 44:C416-C422.

2. Li CH, Breton S, Morrison R, Cannon CL, Emma F, Sanchez-Olea R, Bear C, Strange K.: Recombinant pICln forms highly cation-selective channels when reconstituted into artificial and biological membranes. J Gen Physiol 1998; 112: 727-736.

3. Cullen AR, Cannon CL, Mark EJ, Colin AA: Mycobacterium abscessus infection in cystic fibrosis - colonization or infection? Am J Respir Crit Care Med 2000; 161:641-645.

4. Schroeder TH, Lee MM, Yacono PW, Cannon CL, Gerçeker AA, Golan DE, Pier GB: CFTR is a pattern recognition molecule that activates innate immunity by removing bacterial LPS from the outer membrane. PNAS 2002; 99:6907-6912.

5. Coleman FT, Mueschenborn S, Meluleni G, Ray C, Carey V, Vargas SO, Cannon CL, Ausubel FM, Pier GB: Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection. PNAS 2003; 100:1949-1954.

6. Cannon CL, Kowalski MP, Stopak KS, Pier GB: Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant CFTR. Am J Respir Cell Mol Biol 2003; 29:188-197.