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Francis Sessions Cole, III, M.D.
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Park J. White, M.D. Professor of Pediatrics and Professor of Cell Biology and Physiology
Medical Director of Pediatrics for the BJC Health System
Vice Chairman, Department of Pediatrics
Acting Director The David Goldring Division of Pediatric Cardiology
Director Division of Pediatric Newborn Medicine
Newborn Medicine
Cardiology
Pathobiology
Genetic regulation of neonatal pulmonary surfactant deficiency has been suggested by studies of gender, genetic linkage, recurrent familial cases, targeted gene ablation in murine lineages, and by racial disparity in risk of neonatal respiratory distress syndrome. Successful fetal-neonatal pulmonary transition requires production of the pulmonary surfactant, a phospholipid-protein film that lines alveoli and maintains alveolar patency at end expiration. Our goal is to understand the genetic mechanisms that disrupt pulmonary surfactant metabolism and cause neonatal respiratory distress syndrome
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Appointments
Park J. White, M.D., Professor of Pediatrics, Washington University School of Medicine
Assistant Vice Chancellor for Children's Health
Vice Chairman, Department of Pediatrics
Director, Division of Newborn Medicine
Chief Medical Officer, St. Louis Children's Hospital
Affiliations
St. Louis Children’s Hospital; Barnes-Jewish Hospital
Francis Sessions Cole, III, M.D.
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Park J. White, M.D. Professor of Pediatrics and Professor of Cell Biology and Physiology
Medical Director of Pediatrics for the BJC Health System
Vice Chairman, Department of Pediatrics
Acting Director The David Goldring Division of Pediatric Cardiology
Director Division of Pediatric Newborn Medicine
Newborn Medicine
Cardiology
Pathobiology
Genetic regulation of neonatal pulmonary surfactant deficiency has been suggested by studies of gender, genetic linkage, recurrent familial cases, targeted gene ablation in murine lineages, and by racial disparity in risk of neonatal respiratory distress syndrome. Successful fetal-neonatal pulmonary transition requires production of the pulmonary surfactant, a phospholipid-protein film that lines alveoli and maintains alveolar patency at end expiration. Our goal is to understand the genetic mechanisms that disrupt pulmonary surfactant metabolism and cause neonatal respiratory distress syndrome
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Appointments
Park J. White, M.D., Professor of Pediatrics, Washington University School of Medicine
Assistant Vice Chancellor for Children's Health
Vice Chairman, Department of Pediatrics
Director, Division of Newborn Medicine
Chief Medical Officer, St. Louis Children's Hospital
Affiliations
St. Louis Children’s Hospital; Barnes-Jewish Hospital
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B.A., Amherst College, 1969
M.D., Yale University School of Medicine, 1973
B.A., Amherst College, 1969
M.D., Yale University School of Medicine, 1973
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Internship, Children’s Hospital Medical Center, 1973-1974
Residency, Children's Hospital Medical Center, 1976-1978
Research Fellow in Neonatology and Cell Biology, the Joint Program in Neonatology, Brigham and
Women's Hospital, 1978-1981
Internship, Children’s Hospital Medical Center, 1973-1974
Residency, Children's Hospital Medical Center, 1976-1978
Research Fellow in Neonatology and Cell Biology, the Joint Program in Neonatology, Brigham and
Women's Hospital, 1978-1981
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1975 Massachusetts
1986 Missouri
1973 National Board of Medical Examiners
1980 American Board of Pediatrics
1983 American Board of Neonatal-Perinatal Medicine
1975 Massachusetts
1986 Missouri
1973 National Board of Medical Examiners
1980 American Board of Pediatrics
1983 American Board of Neonatal-Perinatal Medicine
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Invited plenary session speaker, 14th European Congress of Perinatal Medicine, Helsinki, 1994
FDR Leadership Award, March of Dimes, 1997
Named the Park J. White, M.D., Professor of Pediatrics, 1998
Cartíer First Aide Award, St. Louis Effort For AIDS, 2000
Washington University Nominee for the Pfizer Humanism in Medicine Award, 2003
Distinguished Service Teaching Award, Washington University School of Medicine (Class of '07), 2004
Invited plenary session speaker, 14th European Congress of Perinatal Medicine, Helsinki, 1994
FDR Leadership Award, March of Dimes, 1997
Named the Park J. White, M.D., Professor of Pediatrics, 1998
Cartíer First Aide Award, St. Louis Effort For AIDS, 2000
Washington University Nominee for the Pfizer Humanism in Medicine Award, 2003
Distinguished Service Teaching Award, Washington University School of Medicine (Class of '07), 2004
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1. Hamvas A, Wegner DJ, Carlson CS, Bergmann KR, Trusgnich MA, Fulton L, Kasai Y, An P, Mardis ER, Wilson RK, Cole FS. Comprehensive genetic variant discovery in the surfactant protein B gene. Pediatr Res 2007; 62:170-175.
2. Saugstad OD, Hansen TWR, Ronnestad A, Nakstad B, Tollofsrud TA, Reinholt F, Hamvas A, Cole FS, Dean M, Wert SE, Whitsett JA, Nogee LM. Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease. Acta Paediatr 2007; 96:185-190.
3. Garmany TH, Wambach JA, Heins HB, Watkins-Torry JM, Wegner DJ, Bennet K, An P, Land G, Saugstad OD, Henderson H, Nogee LM, Cole FS, Hamvas A. Population and disease-based prevalence of the common mutations associated with surfactant deficiency. Pediatr Res 2008; 63:645-649.
4. McBee AD, Wegner DJ, Carlson CS, Wambach JA, Yang P, Heins HB, Saugstad OD, Trusgnich MA, Watkins-Torry J, Nogee LM, Henderson H, Cole FS, Hamvas A. Recombination as a mechanism for sporadic mutation in the surfactant protein-C gene. Pediatr Pulmon 2008; 43:443-450.
5. Hamvas A, Heins HB, Guttentag SH, Wegner DJ, Trusgnich MA, Bennet KW, Yang P, Carlson CS, An P, Cole FS. Developmental and genetic regulation of surfactant protein-B in vivo. Neonatol 2008; in press.
1. Hamvas A, Wegner DJ, Carlson CS, Bergmann KR, Trusgnich MA, Fulton L, Kasai Y, An P, Mardis ER, Wilson RK, Cole FS. Comprehensive genetic variant discovery in the surfactant protein B gene. Pediatr Res 2007; 62:170-175.
2. Saugstad OD, Hansen TWR, Ronnestad A, Nakstad B, Tollofsrud TA, Reinholt F, Hamvas A, Cole FS, Dean M, Wert SE, Whitsett JA, Nogee LM. Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease. Acta Paediatr 2007; 96:185-190.
3. Garmany TH, Wambach JA, Heins HB, Watkins-Torry JM, Wegner DJ, Bennet K, An P, Land G, Saugstad OD, Henderson H, Nogee LM, Cole FS, Hamvas A. Population and disease-based prevalence of the common mutations associated with surfactant deficiency. Pediatr Res 2008; 63:645-649.
4. McBee AD, Wegner DJ, Carlson CS, Wambach JA, Yang P, Heins HB, Saugstad OD, Trusgnich MA, Watkins-Torry J, Nogee LM, Henderson H, Cole FS, Hamvas A. Recombination as a mechanism for sporadic mutation in the surfactant protein-C gene. Pediatr Pulmon 2008; 43:443-450.
5. Hamvas A, Heins HB, Guttentag SH, Wegner DJ, Trusgnich MA, Bennet KW, Yang P, Carlson CS, An P, Cole FS. Developmental and genetic regulation of surfactant protein-B in vivo. Neonatol 2008; in press.
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