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Neil H. White, M.D., C.D.E.
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Professor of Pediatrics
Director, Pediatric Clinical Research Unit
Co-Unit Leader, Patient Oriented Research Unit
Endocrinology and Diabetes
Patient Oriented Research
Dr. White is a native of New York and trained in chemistry at the State University of New York at Albany, and attended medical school at Albert Einstein College of Medicine in the Bronx , graduating in 1975. He did his post-graduate pediatric and pediatric endocrinology training at St. Louis Children's Hospital and Washington University in St. Louis and then served as an Assistant Professor of Pediatrics in the Division of Endocrinology and Metabolism from 1980-1987.
From 1987 to 1991, he served as Associate Professor of Pediatrics and Communicable Diseases at the University of Michigan School of Medicine, and as Associate Director of the Clinical Implementation Core of the Michigan Diabetes Research and Training Center. Dr. White returned to Washington University in 1991 and is currently a Professor in the Division of Endocrinology and Diabetes. He is also Co-Unit Leader of the Pediatric Patient-Oriented Research Unit (PORU) of the Department of Pediatrics and Director of the Pediatric Clinical Research Unit (PCRU) of the Washington University Institute of Clinical and Translational Sciences (ICTS). He is board certified in pediatrics and pediatric endocrinology and is a Certified Diabetes Educator (CDE).
Dr. White is a member of multiple professional societies including the Professional Section of the American Diabetes Association, the American Federation for Medical Research, the Lawson Wilkins Pediatric Endocrine Society, the Society for Pediatric Research, the American Pediatric Society, the International Society for Pediatric and Adolescent Diabetes (Advisory Board 2009-2011), the Endocrine Society, the International Diabetes Federation, and the Juvenile Diabetes Research Foundation. He has had a longstanding involvement with the American Diabetes Association at the local, state, regional, and national level and has served on many boards and committees. These have included his involvement as a member of the Research Grant Review Panel, the Scientific Sessions Planning Committee, and the Camp Task Force of the American Diabetes Association (ADA), and as Program Chairman and subsequently Chairman of the Council on Diabetes in Youth of the ADA. He is a Past-President of the St. Louis Chapter of the American Diabetes Association. Dr. White has also had more than 25 years of involvement in the organization and operation of camps for diabetic children and was the recipient of the award for Outstanding Contribution to Diabetes and Camping of the American Diabetes Association in 1998.
Research Interests
Over the last 30 years, Dr. White's research interests have included active participation as a co-investigator and subsequently co-principal investigator of the Diabetes Control and Complications Trial (DCCT) both at Washington University and the University of Michigan. He is currently the principal investigator at Washington University for the DCCT/EDIC study. He has had an ongoing interest in the methods of intensive therapy in type 1 and the risk of hypoglycemia as part of this therapy. He also oversees the Diabetes Prevention Program (DPP) and the DPP Outcomes Study (DPPOS), multiple trials of psychosocial interventions in diabetic teenagers, and the local centers of the Type 1 Diabetes TrialNet and TRIGR studies (related to prevention of type 1 diabetes) and the STOPP-T2D/TODAY study (related to treatment and prevention of type 2 diabetes in youth). Recently, he has become involved in the Diabetes Research in Children Network (DirecNet) for which he is the principal investigator at the Washington University site and Chairman of the DirecNet Steering Committee. Dr. White has also been collaborating with Tamara Hershey, Ph.D. , from the Departments of Psychiatry, Neurology and Radiology to study cognitive functioning in children with type 1 diabetes mellitus. These studies have consistently shown persistent effects of severe hypoglycemia on the long delay Spatial Delayed Response Task (SDR) and demonstrate effects of both prior hypoglycemia and hyperglycemia on cognitive function and brain structure (by MRI and DTI) in children with type 1 diabetes mellitus. These studies are continuing in hopes of confirming and expanding these findings. See http://www.nil.wustl.edu/labs/hershey/db.htmfor more information.
Dr. White is supported largely by research grants from NIH/NIDDK/NICHD. He is also supported by the CTSA grant as Director of the Pediatric Clinical Research Unit (PCRU) of the Institute of Clinical and Translational Sciences (ICTS).
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Neil H. White, M.D., C.D.E.
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Professor of Pediatrics
Director, Pediatric Clinical Research Unit
Co-Unit Leader, Patient Oriented Research Unit
Endocrinology and Diabetes
Patient Oriented Research
Dr. White is a native of New York and trained in chemistry at the State University of New York at Albany, and attended medical school at Albert Einstein College of Medicine in the Bronx , graduating in 1975. He did his post-graduate pediatric and pediatric endocrinology training at St. Louis Children's Hospital and Washington University in St. Louis and then served as an Assistant Professor of Pediatrics in the Division of Endocrinology and Metabolism from 1980-1987.
From 1987 to 1991, he served as Associate Professor of Pediatrics and Communicable Diseases at the University of Michigan School of Medicine, and as Associate Director of the Clinical Implementation Core of the Michigan Diabetes Research and Training Center. Dr. White returned to Washington University in 1991 and is currently a Professor in the Division of Endocrinology and Diabetes. He is also Co-Unit Leader of the Pediatric Patient-Oriented Research Unit (PORU) of the Department of Pediatrics and Director of the Pediatric Clinical Research Unit (PCRU) of the Washington University Institute of Clinical and Translational Sciences (ICTS). He is board certified in pediatrics and pediatric endocrinology and is a Certified Diabetes Educator (CDE).
Dr. White is a member of multiple professional societies including the Professional Section of the American Diabetes Association, the American Federation for Medical Research, the Lawson Wilkins Pediatric Endocrine Society, the Society for Pediatric Research, the American Pediatric Society, the International Society for Pediatric and Adolescent Diabetes (Advisory Board 2009-2011), the Endocrine Society, the International Diabetes Federation, and the Juvenile Diabetes Research Foundation. He has had a longstanding involvement with the American Diabetes Association at the local, state, regional, and national level and has served on many boards and committees. These have included his involvement as a member of the Research Grant Review Panel, the Scientific Sessions Planning Committee, and the Camp Task Force of the American Diabetes Association (ADA), and as Program Chairman and subsequently Chairman of the Council on Diabetes in Youth of the ADA. He is a Past-President of the St. Louis Chapter of the American Diabetes Association. Dr. White has also had more than 25 years of involvement in the organization and operation of camps for diabetic children and was the recipient of the award for Outstanding Contribution to Diabetes and Camping of the American Diabetes Association in 1998.
Research Interests
Over the last 30 years, Dr. White's research interests have included active participation as a co-investigator and subsequently co-principal investigator of the Diabetes Control and Complications Trial (DCCT) both at Washington University and the University of Michigan. He is currently the principal investigator at Washington University for the DCCT/EDIC study. He has had an ongoing interest in the methods of intensive therapy in type 1 and the risk of hypoglycemia as part of this therapy. He also oversees the Diabetes Prevention Program (DPP) and the DPP Outcomes Study (DPPOS), multiple trials of psychosocial interventions in diabetic teenagers, and the local centers of the Type 1 Diabetes TrialNet and TRIGR studies (related to prevention of type 1 diabetes) and the STOPP-T2D/TODAY study (related to treatment and prevention of type 2 diabetes in youth). Recently, he has become involved in the Diabetes Research in Children Network (DirecNet) for which he is the principal investigator at the Washington University site and Chairman of the DirecNet Steering Committee. Dr. White has also been collaborating with Tamara Hershey, Ph.D. , from the Departments of Psychiatry, Neurology and Radiology to study cognitive functioning in children with type 1 diabetes mellitus. These studies have consistently shown persistent effects of severe hypoglycemia on the long delay Spatial Delayed Response Task (SDR) and demonstrate effects of both prior hypoglycemia and hyperglycemia on cognitive function and brain structure (by MRI and DTI) in children with type 1 diabetes mellitus. These studies are continuing in hopes of confirming and expanding these findings. See http://www.nil.wustl.edu/labs/hershey/db.htmfor more information.
Dr. White is supported largely by research grants from NIH/NIDDK/NICHD. He is also supported by the CTSA grant as Director of the Pediatric Clinical Research Unit (PCRU) of the Institute of Clinical and Translational Sciences (ICTS).
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Perantie DC, Lim A, Wu J, Weaver P, Warren SL, Hayden T, Christ S, Sadler M, White NH, Hershey T: Effects of prior history of hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus. Pediatric Diabetes 9(2):87-95, 2008. [PMID: 18208449] -
Perantie DC, Wu J, Koller JM, Lim A, Warren S, Black KJ, Sadler M, White NH, Hershey T: Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes. Diabetes Care 30(9):2331-2337, 2007 -
Hershey T, Perantie DC, Warren SL, Zimmerman EC, Sadler M, White NH: Frequency and timing of severe hypoglycemia affects spatial memory in children with type 1 diabetes mellitus. Diabetes Care 28:2372-2377, 2005 Chase HP, Arslanian S, White NH, Tamborlane WV: Insulin glargine vs. intermediate-acting insulin as the basal component of multiple daily injection regimens for adolescents with type 1 diabetes. The Journal of Pediatrics 153:547-553, 2008. [PMID: 18589448] Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group: Prolonged effect of intensive therapy on the risk of retinopathy complications in patient with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Archives of Ophthalmology 126(12):1707-1715, 2008. [PMID: 19064853] [Written by NH White, W. Sun, PA Cleary, RP Danis, MD Davis, DP Hainsworth, LD Hubbard, JM Lachin and DM Nathan for the DCCT Research Group] Harris MA, Antal H, Oelbaum R, Buckloh LM, White NH, Wysocki T: Good intentions gone awry: Assessing parental “miscarried helping” in diabetes. Families, Systems & Health 26(4):393-403, 2008 White NH, Chase HP, Arslanian S, Tamborlane WV for the 4030 Study Group: Comparison of glycemic variability associated with insulin glargine and intermediate-acting insulin when used as the basal component of multiple daily injections for adolescents with type 1 diabetes. Diabetes Care, 32(3):387-393, 2009. [PMID: 19106380] Wambach JA, Marshall BA, Koster JC, White NH, Nichols CG: Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation. Pediatric Diabetes, (E.published ahead of print), 2009. [PMID: 19656320] The DCCT/Epidemiology of Diabetes Interventions and Complications Research Group: Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes: The importance of glycemic control in the persistence of “metabolic memory”. [Writing group: White NH, Cleary PA, et al], Diabetes, In Press, 2009. Hershey T, Perantie DC, Wu J, Weaver PM, Black KJ, White NH: Hippocampal volumes in youth with type 1 diabetes mellitus (T1DM) Diabetes, In Press, 2009. White NH, Skor DA, Cryer PE, Levandoski LA, Bier DM, Santiago JV. Identification of type I diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med. 1983. 308(9):485-91.
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Perantie DC, Lim A, Wu J, Weaver P, Warren SL, Hayden T, Christ S, Sadler M, White NH, Hershey T: Effects of prior history of hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus. Pediatric Diabetes 9(2):87-95, 2008. [PMID: 18208449] -
Perantie DC, Wu J, Koller JM, Lim A, Warren S, Black KJ, Sadler M, White NH, Hershey T: Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes. Diabetes Care 30(9):2331-2337, 2007 -
Hershey T, Perantie DC, Warren SL, Zimmerman EC, Sadler M, White NH: Frequency and timing of severe hypoglycemia affects spatial memory in children with type 1 diabetes mellitus. Diabetes Care 28:2372-2377, 2005 Chase HP, Arslanian S, White NH, Tamborlane WV: Insulin glargine vs. intermediate-acting insulin as the basal component of multiple daily injection regimens for adolescents with type 1 diabetes. The Journal of Pediatrics 153:547-553, 2008. [PMID: 18589448] Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group: Prolonged effect of intensive therapy on the risk of retinopathy complications in patient with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Archives of Ophthalmology 126(12):1707-1715, 2008. [PMID: 19064853] [Written by NH White, W. Sun, PA Cleary, RP Danis, MD Davis, DP Hainsworth, LD Hubbard, JM Lachin and DM Nathan for the DCCT Research Group] Harris MA, Antal H, Oelbaum R, Buckloh LM, White NH, Wysocki T: Good intentions gone awry: Assessing parental “miscarried helping” in diabetes. Families, Systems & Health 26(4):393-403, 2008 White NH, Chase HP, Arslanian S, Tamborlane WV for the 4030 Study Group: Comparison of glycemic variability associated with insulin glargine and intermediate-acting insulin when used as the basal component of multiple daily injections for adolescents with type 1 diabetes. Diabetes Care, 32(3):387-393, 2009. [PMID: 19106380] Wambach JA, Marshall BA, Koster JC, White NH, Nichols CG: Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation. Pediatric Diabetes, (E.published ahead of print), 2009. [PMID: 19656320] The DCCT/Epidemiology of Diabetes Interventions and Complications Research Group: Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes: The importance of glycemic control in the persistence of “metabolic memory”. [Writing group: White NH, Cleary PA, et al], Diabetes, In Press, 2009. Hershey T, Perantie DC, Wu J, Weaver PM, Black KJ, White NH: Hippocampal volumes in youth with type 1 diabetes mellitus (T1DM) Diabetes, In Press, 2009. White NH, Skor DA, Cryer PE, Levandoski LA, Bier DM, Santiago JV. Identification of type I diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med. 1983. 308(9):485-91.
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