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Faculty Bio

Duncan, Jennifer Gries, M.D.

Assistant Professor of Pediatrics

Critical Care Medicine
Developmental Biology and Genetics Research Unit
Duncan Lab
Children's Discovery Institute

Dr. Duncan is an attending physician in the Division of Critical Care Medicine and a member of the Developmental Biology and Genetics Research Unit. She received her medical degree from The University of Chicago Pritzker School of Medicine and did her residency at The University of Chicago Children’s Hospital. She completed a pediatric critical care fellowship at Johns Hopkins University and joined the faculty at Washington University School of Medicine in 2004. She is board certified in pediatrics and pediatric critical care medicine. She is a member of the American Academy of Pediatrics, the American Heart Association and the Society for Critical Care Medicine.

Dr. Duncan’s research interests center around cardiac metabolism and bioenergetics in diseased hearts. Utilizing mouse models of insulin resistance and diabetes she is studying the effects of excess circulating fatty acid on energy metabolism. Dr. Duncan is particularly interested in understanding the control of cardiac mitochondrial biogenesis and metabolism and the consequences of mitochondrial dysfunction on energy production during pathologic states. She has recently been exploring avenues to apply these studies to alterations in mitochondrial metabolism during development.

Duncan, Jennifer Gries, M.D.

Assistant Professor of Pediatrics

Critical Care Medicine
Developmental Biology and Genetics Research Unit
Duncan Lab
Children's Discovery Institute

Dr. Duncan is an attending physician in the Division of Critical Care Medicine and a member of the Developmental Biology and Genetics Research Unit. She received her medical degree from The University of Chicago Pritzker School of Medicine and did her residency at The University of Chicago Children’s Hospital. She completed a pediatric critical care fellowship at Johns Hopkins University and joined the faculty at Washington University School of Medicine in 2004. She is board certified in pediatrics and pediatric critical care medicine. She is a member of the American Academy of Pediatrics, the American Heart Association and the Society for Critical Care Medicine.

Dr. Duncan’s research interests center around cardiac metabolism and bioenergetics in diseased hearts. Utilizing mouse models of insulin resistance and diabetes she is studying the effects of excess circulating fatty acid on energy metabolism. Dr. Duncan is particularly interested in understanding the control of cardiac mitochondrial biogenesis and metabolism and the consequences of mitochondrial dysfunction on energy production during pathologic states. She has recently been exploring avenues to apply these studies to alterations in mitochondrial metabolism during development.

Education
  • B.S., Vanderbilt University, 1993 (molecular biology)
  • M.D., University of Chicago Pritzker School of Medicine, 1997
  • B.S., Vanderbilt University, 1993 (molecular biology)
  • M.D., University of Chicago Pritzker School of Medicine, 1997
Training
  • Pediatric Resident, The University of Chicago Children’s Hospital (1997-2000)
  • Pediatric Chief Resident, The University of Chicago Children’s Hospital (2000-2001)
  • Pediatric Critical Care Fellow, Johns Hopkins University (2001-2004)
  • Pediatric Resident, The University of Chicago Children’s Hospital (1997-2000)
  • Pediatric Chief Resident, The University of Chicago Children’s Hospital (2000-2001)
  • Pediatric Critical Care Fellow, Johns Hopkins University (2001-2004)
Licensure and Board Certification
  • American Board of Pediatrics, General Pediatrics, 2000
  • State of Missouri, Medical License 2004
  • American Board of Pediatrics, Pediatric Critical Care, 2004
  • American Board of Pediatrics, General Pediatrics, 2000
  • State of Missouri, Medical License 2004
  • American Board of Pediatrics, Pediatric Critical Care, 2004
Honors
  • Scholar of the Children’s Discovery Institute
  • Scholar of the Child Health Research Center of Excellence in Developmental Biology
  • Graduation with Honors, Pritzker School of Medicine, 1997
  • The Pediatrics Departmental Award given for most meritorious research involving children or developmental biology, 1997
  • Scholar of the Children’s Discovery Institute
  • Scholar of the Child Health Research Center of Excellence in Developmental Biology
  • Graduation with Honors, Pritzker School of Medicine, 1997
  • The Pediatrics Departmental Award given for most meritorious research involving children or developmental biology, 1997
Selected Publications
  1. Duncan, JG, Rajashree R, Stull LB, Murphy AM: Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy. Am J Physiol (Heart Circ), 289: H1512-1518, 2005.

  2. Bilchick KC*, Duncan JG*, Ravi R, Takimoto E, Champion HC, Gao WD, Stull LB, Kass DA, Murphy AM: Heart failure-associated alterations in troponin I phosphorylation impair ventricular relaxation-afterload and force-frequency responses and systolic function. Am J Physiol (Heart Circ), 292: H318-25, 2007.

  3. Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP: The insulin-resistant heart exhibits a mitochondrial biogenic response driven by the PPARα -PGC-1α regulatory pathway. Circulation, 115: 909-917, 2007.

  4. Duncan JG and Finck BN: The PPARα-PGC-1α axis controls cardiac energy metabolism in healthy and diseased myocardium. PPAR Research 2008: 253817, 2008

  5. Duncan, JG: Lipotoxicity: What is the Fate of Fatty Acids? Journal of Lipid Research, 49:1375-1376, 2008.

  1. Duncan, JG, Rajashree R, Stull LB, Murphy AM: Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy. Am J Physiol (Heart Circ), 289: H1512-1518, 2005.

  2. Bilchick KC*, Duncan JG*, Ravi R, Takimoto E, Champion HC, Gao WD, Stull LB, Kass DA, Murphy AM: Heart failure-associated alterations in troponin I phosphorylation impair ventricular relaxation-afterload and force-frequency responses and systolic function. Am J Physiol (Heart Circ), 292: H318-25, 2007.

  3. Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP: The insulin-resistant heart exhibits a mitochondrial biogenic response driven by the PPARα -PGC-1α regulatory pathway. Circulation, 115: 909-917, 2007.

  4. Duncan JG and Finck BN: The PPARα-PGC-1α axis controls cardiac energy metabolism in healthy and diseased myocardium. PPAR Research 2008: 253817, 2008

  5. Duncan, JG: Lipotoxicity: What is the Fate of Fatty Acids? Journal of Lipid Research, 49:1375-1376, 2008.

 
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