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Scott Saunders, M.D., Ph.D.
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Associate Professor of Pediatrics
Associate Professor of Developmental Biology
Newborn Medicine
Developmental Biology and Genetics
One of our primary focuses in our lab is on understanding the role of heparan sulfate proteoglycans in the control of cellular responses to components of the extracellular space during development.
Heparan sulfate proteoglycans represent a unique class of developmentally regulated glycoproteins which bind to and regulate a wide range of extracellular proteins including growth factors and their binding proteins, structural extracellular matrix proteins, proteases, and protease inhibitors...
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Scott Saunders, M.D., Ph.D.
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Associate Professor of Pediatrics
Associate Professor of Developmental Biology
Newborn Medicine
Developmental Biology and Genetics
One of our primary focuses in our lab is on understanding the role of heparan sulfate proteoglycans in the control of cellular responses to components of the extracellular space during development.
Heparan sulfate proteoglycans represent a unique class of developmentally regulated glycoproteins which bind to and regulate a wide range of extracellular proteins including growth factors and their binding proteins, structural extracellular matrix proteins, proteases, and protease inhibitors...
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- BS, University of Minnesota (Biochemistry), Minneapolis, MN, 1983
- MD, Stanford University School of Medicine, Stanford, CA, 1990
- PhD, Stanford University School of Medicine, Stanford, CA, 1990
- BS, University of Minnesota (Biochemistry), Minneapolis, MN, 1983
- MD, Stanford University School of Medicine, Stanford, CA, 1990
- PhD, Stanford University School of Medicine, Stanford, CA, 1990
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- Resident in Medicine, Children's Hospital, Boston, MA, 1990 - 1993
- Postdoc Fellow, Brain & Cognitive Sciences Massachusetts Institute of Technology, MA, 1993 - 1995
- Clinical Fellow in Newborn Medicine, Joint Program in Neonatology, Harvard Medical School Boston, MA, 1993 - 1996
- Resident in Medicine, Children's Hospital, Boston, MA, 1990 - 1993
- Postdoc Fellow, Brain & Cognitive Sciences Massachusetts Institute of Technology, MA, 1993 - 1995
- Clinical Fellow in Newborn Medicine, Joint Program in Neonatology, Harvard Medical School Boston, MA, 1993 - 1996
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- Missouri, 1997 - 2009
- American Board of Pediatrics, General Pediatrics Certification, 1993 - 2008
- American Board of Pediatrics, Neonatal-Perinatal Medicine Certification, 2008 - 2015
- Missouri, 1997 - 2009
- American Board of Pediatrics, General Pediatrics Certification, 1993 - 2008
- American Board of Pediatrics, Neonatal-Perinatal Medicine Certification, 2008 - 2015
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- Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians, 1994
- Medical Student Research Award, Society for Pediatric Research, 1989
- Reynolds Rich Smith Fellowship in Development and Function of the Central Nervous System, 1994
- Basil O'Connor Starter Scholar Research Award, March of Dimes Birth Defects Foundation, 1997
- Spoehrer Scholar Award, Department of Pediatrics, Washington University School of Medicine, 1999
- Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians, 1994
- Medical Student Research Award, Society for Pediatric Research, 1989
- Reynolds Rich Smith Fellowship in Development and Function of the Central Nervous System, 1994
- Basil O'Connor Starter Scholar Research Award, March of Dimes Birth Defects Foundation, 1997
- Spoehrer Scholar Award, Department of Pediatrics, Washington University School of Medicine, 1999
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- Saunders S, Martin R. DeBaun MR. Glypican-3: Simpson-Golabi-Behmel syndrome. In Molecular Basis of Inborn Errors of Development, (Epstein CJ, Erickson RP, Wynshaw-Boris A, eds.) Oxford University Press, New York, 2008
- Viviano BL, Paine-Saunders S, Gasiunas N, Gallagher JT, Saunders S. Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin. J. Biol Chem, 2004, 279:5604-5611
- Viviano BL, Silverstein L, Pflederer C, Paine-Saunders S, Mills K, Saunders S. Altered hematopoiesis in Glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification. Dev Biol, 2005, 282:152-162.
- Vachharajani A and Saunders S. Allelic variation in the serotinin transporter (5 HTT) gene contributes to idiopathic pulmonary hypertension in children. Biochem. Biophys. Res. Commun. 2005, 334:376-379.
- Ellies DL, Viviano B, McCarthy J, Rey J-P, Itasaki N, Saunders S, and Krumlauf R. Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRPG171V to modulate Wnt activity. J. Bone Miner. Res., 2006, 21:1738-1749.
- Saunders S, Martin R. DeBaun MR. Glypican-3: Simpson-Golabi-Behmel syndrome. In Molecular Basis of Inborn Errors of Development, (Epstein CJ, Erickson RP, Wynshaw-Boris A, eds.) Oxford University Press, New York, 2008
- Viviano BL, Paine-Saunders S, Gasiunas N, Gallagher JT, Saunders S. Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin. J. Biol Chem, 2004, 279:5604-5611
- Viviano BL, Silverstein L, Pflederer C, Paine-Saunders S, Mills K, Saunders S. Altered hematopoiesis in Glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification. Dev Biol, 2005, 282:152-162.
- Vachharajani A and Saunders S. Allelic variation in the serotinin transporter (5 HTT) gene contributes to idiopathic pulmonary hypertension in children. Biochem. Biophys. Res. Commun. 2005, 334:376-379.
- Ellies DL, Viviano B, McCarthy J, Rey J-P, Itasaki N, Saunders S, and Krumlauf R. Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRPG171V to modulate Wnt activity. J. Bone Miner. Res., 2006, 21:1738-1749.
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