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David A. Rudnick, M.D., Ph.D.
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Assistant Professor
Gastroenterology and Nutrition
Developmental Biology and Genetics
Dr. David Rudnick received his B.S. in Chemistry from the University of Illinois, then completed M.D. and Ph.D. studies at Washington University School of Medicine. His Ph.D. in Molecular Biology and Biochemistry was done with Dr. Jeffrey Gordon's lab and focused on elucidating the biochemical reaction mechanism and substrate specificity of protein-N-myristoylation. He completed Pediatric Residency and Pediatric Gastroenterology Fellowship training at St. Louis Children's Hospital and Washington University School of Medicine. After clinical training, he began post-doctoral work investigating mechanisms of liver regeneration. He joined the faculty in 2000.
In addition to attending on the in-patient GI service, in the out-patient GI office, and in the Procedure Center, he continues to conduct NIH- and foundation-supported research focused on investigating the mechanisms that regulate liver regeneration.
His lab uses the rodent partial hepatectomy model system to investigate liver regeneration in genetically- and pharmacologically-manipulated mice. Recently, they identified a novel adipogenic program activated during and required for a normal regenerative response. These and other observations have led them to hypothesize that liver regeneration is initiated by a signal that derives from the body mass in conditions of hepatic insufficiency. Based on this, they have begun to investigate mechanisms of liver regeneration in a completely novel way, by using an integrated systems biology approach to investigate the nature and functional role of candidate extrahepatic signaling events on recovery of liver mass following hepatic injury. These studies should provide fundamental new insight into mechanisms of liver regeneration. Such insight could ultimately translate into novel, regeneration-based strategies for diagnosing and managing acute and chronic pediatric and adult liver diseases.
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David A. Rudnick, M.D., Ph.D.
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Assistant Professor
Gastroenterology and Nutrition
Developmental Biology and Genetics
Dr. David Rudnick received his B.S. in Chemistry from the University of Illinois, then completed M.D. and Ph.D. studies at Washington University School of Medicine. His Ph.D. in Molecular Biology and Biochemistry was done with Dr. Jeffrey Gordon's lab and focused on elucidating the biochemical reaction mechanism and substrate specificity of protein-N-myristoylation. He completed Pediatric Residency and Pediatric Gastroenterology Fellowship training at St. Louis Children's Hospital and Washington University School of Medicine. After clinical training, he began post-doctoral work investigating mechanisms of liver regeneration. He joined the faculty in 2000.
In addition to attending on the in-patient GI service, in the out-patient GI office, and in the Procedure Center, he continues to conduct NIH- and foundation-supported research focused on investigating the mechanisms that regulate liver regeneration.
His lab uses the rodent partial hepatectomy model system to investigate liver regeneration in genetically- and pharmacologically-manipulated mice. Recently, they identified a novel adipogenic program activated during and required for a normal regenerative response. These and other observations have led them to hypothesize that liver regeneration is initiated by a signal that derives from the body mass in conditions of hepatic insufficiency. Based on this, they have begun to investigate mechanisms of liver regeneration in a completely novel way, by using an integrated systems biology approach to investigate the nature and functional role of candidate extrahepatic signaling events on recovery of liver mass following hepatic injury. These studies should provide fundamental new insight into mechanisms of liver regeneration. Such insight could ultimately translate into novel, regeneration-based strategies for diagnosing and managing acute and chronic pediatric and adult liver diseases.
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1987 BS (Chemistry), University of Illinois, Urbana, Illinois
1994 MD, Washington University School of Medicine, St. Louis, MO
1994 PhD (Molecular Biology and Biochemistry), Washington University School of Medicine, St. Louis, MO
1987 BS (Chemistry), University of Illinois, Urbana, Illinois
1994 MD, Washington University School of Medicine, St. Louis, MO
1994 PhD (Molecular Biology and Biochemistry), Washington University School of Medicine, St. Louis, MO
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1994 - 1995 Internship, St. Louis Children's Hospital
1995 - 1997 Residency, St. Louis Children's Hospital
1997 - 2000 Fellowship in Pediatric Gastroenterology and Nutrition, Washington University School of Medicine, St. Louis Children's Hospital
1994 - 1995 Internship, St. Louis Children's Hospital
1995 - 1997 Residency, St. Louis Children's Hospital
1997 - 2000 Fellowship in Pediatric Gastroenterology and Nutrition, Washington University School of Medicine, St. Louis Children's Hospital
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1997-Present License: Missouri
1997 American Board of Pediatrics, General Pediatrics
2001 American Board of Pediatrics, Sub-board of Pediatric Gastroenterology
2004 American Board of Pediatrics, General Pediatrics, Recertification
2008 American Board of Pediatrics, Sub-board of Pediatric Gastroenterology, Recertification
1997-Present License: Missouri
1997 American Board of Pediatrics, General Pediatrics
2001 American Board of Pediatrics, Sub-board of Pediatric Gastroenterology
2004 American Board of Pediatrics, General Pediatrics, Recertification
2008 American Board of Pediatrics, Sub-board of Pediatric Gastroenterology, Recertification
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1987 Phi Beta Kappa, University of Illinois chapter
1987 Summa Cum Laude, University of Illinois
1992 Spencer T. and Ann W. Olin Foundation Medical Scientist Predoctoral Fellowship, Washington University Medical School (WUMS)
1992 American Federation for Clinical Research, Medical Student Award, WUMS
1993 American College of Physicians Award for Excellence in Physical Diagnosis, WUMS
1994 Alpha Omega Alpha, WUMS
1994 The Dr. Phillip Needleman Pharmacology Award, WUMS
1994 The George F. Gill Prize in Pediatrics, WUMS
2000 Scholar of the Child Health Research Center of Excellence, WUMS
2003 NASPGHAN Young Faculty Investigator Award
2003 Research Excellence in GI and Liver (REGAL) Award
2007-2009 Best Doctors in America
2008 WUMS Distinguished Investigator Award
1987 Phi Beta Kappa, University of Illinois chapter
1987 Summa Cum Laude, University of Illinois
1992 Spencer T. and Ann W. Olin Foundation Medical Scientist Predoctoral Fellowship, Washington University Medical School (WUMS)
1992 American Federation for Clinical Research, Medical Student Award, WUMS
1993 American College of Physicians Award for Excellence in Physical Diagnosis, WUMS
1994 Alpha Omega Alpha, WUMS
1994 The Dr. Phillip Needleman Pharmacology Award, WUMS
1994 The George F. Gill Prize in Pediatrics, WUMS
2000 Scholar of the Child Health Research Center of Excellence, WUMS
2003 NASPGHAN Young Faculty Investigator Award
2003 Research Excellence in GI and Liver (REGAL) Award
2007-2009 Best Doctors in America
2008 WUMS Distinguished Investigator Award
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Rudnick, D.A., Perlmutter, D.H., and Muglia L.J., Prostaglandins are required for CREB Activation and Cellular Proliferation During Liver Regeneration, Proc. Natl. Acad Sci. USA 98, 8885-8890 (2001).
Rudnick, D.A., An, J-K, Muglia, L.J., Perlmutter D.H., and Teckman, J.H., Analyses of Hepatocellular Proliferation in a Mouse Model of Alpha-1-Antitrypsin Deficiency, Hepatology; 39, 1048-1055 (2004).
Liao Y, Shikapwashya O, Shteyer E, Dieckgraefe BK, Hruz PW, and Rudnick DA, Delayed Hepatocellular Mitotic Progression and Impaired Liver Regeneration in Early-Growth-Response-1 Deficient Mice, J. Biol. Chem, 41, 43107-43116 (2004).
Shteyer E, Liao Y, Muglia LJ, Hruz P, Rudnick DA, Disruption of Hepatic Adipogenesis is Associated with Impaired Liver Regeneration, Hepatology, 40, 1322-1332, (2004).
Rudnick DA, Shikapwashya O, Blomenkamp K, and Teckman JH, NSAIDs Increase Liver Injury in a Murine Model of Alpha-1-Antritrypsin Deficiency, Hepatology, 44: 976-982, (2006).
Turmelle YP, Shikapwashya O, Tu S, Hruz, PW, Yan Q, and Rudnick DA, Rosiglitazone Inhibits Liver Regeneration, The FASEB Journal, 20, 2609-2611 (2006).
Clark A, Weymann A, Hartman E, Turmelle Y, Carroll M, Thurman JM, Holers VM, Hourcade DE, and Rudnick DA, Evidence for Non-traditional Activation of Complement Factor C3 During Murine Liver Regeneration, Molecular Immunology, 45, 3125-3132 (2008). PMCID: PMC2600895
Rudnick DA, Dietzen DJ, Turmelle Y, Shepherd R, Zhang S, Belle S, Squires R, and the Pediatric Acute Liver Failure Study Group, Serum a-NH2-Butyric Acid May Predict Spontaneous Survival in Pediatric Acute Liver Failure, Pediatric Transplantation, 13, 223-230 (2009). PMCID: PMC2659723.
Weymann A, Hartman E, Gazit V, Wang C, Glauber M, Turmelle Y, and Rudnick DA, p21 is Required for Dextrose-Mediated Inhibition of Mouse Liver Regeneration, Hepatology, 50, 207-215 (2009). PMCID: PMC2705473.
Qiu Z, Longshore SW, Warner BW, and Rudnick DA, Murine Functional Liver Mass is Reduced Following Partial Small Bowel Resection, Journal of Gastrointestinal Surgery, In Press (2009). PMC Journal – Process.
Rudnick, D.A., Perlmutter, D.H., and Muglia L.J., Prostaglandins are required for CREB Activation and Cellular Proliferation During Liver Regeneration, Proc. Natl. Acad Sci. USA 98, 8885-8890 (2001).
Rudnick, D.A., An, J-K, Muglia, L.J., Perlmutter D.H., and Teckman, J.H., Analyses of Hepatocellular Proliferation in a Mouse Model of Alpha-1-Antitrypsin Deficiency, Hepatology; 39, 1048-1055 (2004).
Liao Y, Shikapwashya O, Shteyer E, Dieckgraefe BK, Hruz PW, and Rudnick DA, Delayed Hepatocellular Mitotic Progression and Impaired Liver Regeneration in Early-Growth-Response-1 Deficient Mice, J. Biol. Chem, 41, 43107-43116 (2004).
Shteyer E, Liao Y, Muglia LJ, Hruz P, Rudnick DA, Disruption of Hepatic Adipogenesis is Associated with Impaired Liver Regeneration, Hepatology, 40, 1322-1332, (2004).
Rudnick DA, Shikapwashya O, Blomenkamp K, and Teckman JH, NSAIDs Increase Liver Injury in a Murine Model of Alpha-1-Antritrypsin Deficiency, Hepatology, 44: 976-982, (2006).
Turmelle YP, Shikapwashya O, Tu S, Hruz, PW, Yan Q, and Rudnick DA, Rosiglitazone Inhibits Liver Regeneration, The FASEB Journal, 20, 2609-2611 (2006).
Clark A, Weymann A, Hartman E, Turmelle Y, Carroll M, Thurman JM, Holers VM, Hourcade DE, and Rudnick DA, Evidence for Non-traditional Activation of Complement Factor C3 During Murine Liver Regeneration, Molecular Immunology, 45, 3125-3132 (2008). PMCID: PMC2600895
Rudnick DA, Dietzen DJ, Turmelle Y, Shepherd R, Zhang S, Belle S, Squires R, and the Pediatric Acute Liver Failure Study Group, Serum a-NH2-Butyric Acid May Predict Spontaneous Survival in Pediatric Acute Liver Failure, Pediatric Transplantation, 13, 223-230 (2009). PMCID: PMC2659723.
Weymann A, Hartman E, Gazit V, Wang C, Glauber M, Turmelle Y, and Rudnick DA, p21 is Required for Dextrose-Mediated Inhibition of Mouse Liver Regeneration, Hepatology, 50, 207-215 (2009). PMCID: PMC2705473.
Qiu Z, Longshore SW, Warner BW, and Rudnick DA, Murine Functional Liver Mass is Reduced Following Partial Small Bowel Resection, Journal of Gastrointestinal Surgery, In Press (2009). PMC Journal – Process.
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