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Faculty Bio

Pineda Soto, Jose A., M.D.

Assistant Professor of Pediatrics and Neurology
Director, Neurocritical Care Program

Critical Care Medicine
Neurology
Neurocritical Care Program 
Patient Oriented Research

Dr. Jose Pineda is Assistant Professor of Pediatrics and Neurology and Director of the Pediatric Neurocritical Care Program.
Following residency in Pediatrics at the University of South Florida, he completed training in Pediatric Critical Care Medicine at Duke University, which included research training at Duke University’s Multidisciplinary Neuroprotection Laboratory. After fellowship training Dr. Pineda joined the faculty the Department of Pediatrics and the McKnight Brain Institute of the University of Florida, where he conducted laboratory and clinical research studies of traumatic brain injury (TBI). Dr. Pineda was recruited to Washington University due to his expertise as a Pediatric Intensivist and his clinical experience and interest in children with brain injury. In parallel to the development of robust clinical expertise, he has successfully conducted research investigating the mechanisms of TBI and potential new treatments for brain injury.

Pineda Soto, Jose A., M.D.

Assistant Professor of Pediatrics and Neurology
Director, Neurocritical Care Program

Critical Care Medicine
Neurology
Neurocritical Care Program 
Patient Oriented Research

Dr. Jose Pineda is Assistant Professor of Pediatrics and Neurology and Director of the Pediatric Neurocritical Care Program.
Following residency in Pediatrics at the University of South Florida, he completed training in Pediatric Critical Care Medicine at Duke University, which included research training at Duke University’s Multidisciplinary Neuroprotection Laboratory. After fellowship training Dr. Pineda joined the faculty the Department of Pediatrics and the McKnight Brain Institute of the University of Florida, where he conducted laboratory and clinical research studies of traumatic brain injury (TBI). Dr. Pineda was recruited to Washington University due to his expertise as a Pediatric Intensivist and his clinical experience and interest in children with brain injury. In parallel to the development of robust clinical expertise, he has successfully conducted research investigating the mechanisms of TBI and potential new treatments for brain injury.
Education
  • B.A., Universidad Francisco Marroquin School of Medicine (Biology), Guatemala, 1988
  • M.D., Universidad Francisco Marroquin School of Medicine, Guatemala, 1993
  • B.A., Universidad Francisco Marroquin School of Medicine (Biology), Guatemala, 1988
  • M.D., Universidad Francisco Marroquin School of Medicine, Guatemala, 1993
Training
  • Resident in Pediatrics, University of South Florida, 1994-1997
  • Fellow in Pediatrics Critical Care Medicine and Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, 1997-2001
  • Resident in Pediatrics, University of South Florida, 1994-1997
  • Fellow in Pediatrics Critical Care Medicine and Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, 1997-2001
Licensure and Board Certification
  • Missouri License, 2005
  • Guatemala License, 1994
  • Florida License, 2002
  • American Board of Pediatrics,
  • Sub-board, Pediatric Critical Care Medicine,
  • Pediatric Advanced Pediatric Life Support Instrucotr (AHA/AAP)
  • Missouri License, 2005
  • Guatemala License, 1994
  • Florida License, 2002
  • American Board of Pediatrics,
  • Sub-board, Pediatric Critical Care Medicine,
  • Pediatric Advanced Pediatric Life Support Instrucotr (AHA/AAP)
Honors
  • Honor Roll, Liceo Javier, 1984
  • Top ten in the Class of 94, UFM School of Medicine, 1994
  • Service Excellence Award, All Children's Hospital
  • Outstanding Medical Student Teaching, Department of Pediatrics, University of South Florida
  • 1st Place Physician Research Award, 17th Annual Scientific Symposium, Society of Critical Care Medicine, Carolina/Virginia Chapter, Williamsburg, VA June 1999
  • Research Award -Finalist, Department of Anesthesiology Academic Evening, DUMC, Durham, NC, 2000
  • 1st Place Physician Research Award, 18th Annual Scientific Symposium, Society of Critical Care Medicine, Carolina/Virginia Chapter, Williamsburg, VA June 2000
  • Children’s Miracle Network 2001 Fall Award
  • Howard Hughes Medical Institute Biomedical Research Support Program- New Faculty Start Up Award
  • Clinical Science Poster Presentation Award, UF College of Medicine Research Day, April 27 2004

  • Outstanding Division Teaching Award, Department of Pediatrics, Washington University School of Medicine, 2005-2006

  • Honor Roll, Liceo Javier, 1984
  • Top ten in the Class of 94, UFM School of Medicine, 1994
  • Service Excellence Award, All Children's Hospital
  • Outstanding Medical Student Teaching, Department of Pediatrics, University of South Florida
  • 1st Place Physician Research Award, 17th Annual Scientific Symposium, Society of Critical Care Medicine, Carolina/Virginia Chapter, Williamsburg, VA June 1999
  • Research Award -Finalist, Department of Anesthesiology Academic Evening, DUMC, Durham, NC, 2000
  • 1st Place Physician Research Award, 18th Annual Scientific Symposium, Society of Critical Care Medicine, Carolina/Virginia Chapter, Williamsburg, VA June 2000
  • Children’s Miracle Network 2001 Fall Award
  • Howard Hughes Medical Institute Biomedical Research Support Program- New Faculty Start Up Award
  • Clinical Science Poster Presentation Award, UF College of Medicine Research Day, April 27 2004

  • Outstanding Division Teaching Award, Department of Pediatrics, Washington University School of Medicine, 2005-2006
Selected Publications
  1. Nellgard B, Mackensen GB, Pineda J, Wellons JC, Pearlstein RD, Warner DS: Anesthetic Effects on Cerebral Metabolic Rate Predict Histologic Outcome from Near-complete Forebrain Ischemia in the Rat. Anesthesiology. 93(2):431-436, August 2000.
  2.  Pineda JA, Aono M, Sheng H, Lynch J, Wellons JC, Laskowitz DT, Pearlstein RD, Bowler R, Crapo J, Warner DS: Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse. J Neurotrauma. 2001 Jun;18(6):625-34.
  3. Lynch JR, Pineda JA, Morgan D, Zhang L, Warner DS, Benveniste H, Laskowitz DT: Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol. 2002 Jan;51(1):113-7.
  4. Mackensen GB, Sato Y, Nellgard B, Pineda J, Newman MF, Warner DS, Grocott HP: Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 2001 Dec;95(6):1485-91.
  5. Modell JH, Idris AH, Pineda JA, Silverstein JH: Survival after prolonged submersion in freshwater in Florida. Chest; 125(5): 1948-51, May 2004.
  6. Wainwright MS, Craft JM, Griffin WS, Marks A, Pineda J, Padgett K, Van Eldik L: Increased Susceptibility of S100B Transgenic Mice to Perinatal Hypoxia-Ischemia. Ann Neurol. 2004 Jul;56(1):61-7.
  7. Johnson E, Pike BR, Tolentino P, Shaw G, Kampfl A, Wang KWW, Hayes RL, Pineda JA: Up-regulation of the Cell Cycle Protein, Survivin, in Astrocytes and Neurons After Experimental Traumatic Brain Injury in Rats. J Neurotrauma. 2004 Sep; 21(9):1183-95.
  8. Ringger NC, O'Steen BE, Brabham JG, Silver X, Pineda J, Wang KKW, Hayes RL, Papa L: A Novel Marker for Traumatic Brain Injury: CSF II-Spectrin Breakdown Product Levels. J Neurotrauma. 2004 Oct; 21(10): 1443-56.
  9. WE. Haskins, FH. Kobeissy, RA. Wolper, AK Ottens, JW Kitlen, MC Liu, SH McClung, AG Lundberg, Barbara E. O'Steen, Marjorie M. Chow, JA Pineda, Nancy D. Denslow, Ronald L. Hayes, Kevin K.W. Wang. Rapid Discovery of Putative Protein Biomarkers of Traumatic Brain Injury by SDS-PAGE-Capillary Liquid Chromatography-Tandem Mass Spectrometry. J Neurotrauma. 2005 Jun;22(6):629-44.
  10. Erik A. Johnson, Stanislav I. Svetlov, Kevin K.W. Wang, Ronald L. Hayes, JA Pineda: Cell-specific DNA Fragmentation May Be Attenuated by a Survivin-dependent Mechanism Following Traumatic Brain Injury in Rats. Exp Brain Res. 2005 Nov;167(1):17-26.
  11. Aikman JM, Osteen BE, Silver X, Torres R, Boslaugh S, Blackband S, Padgett K, Wang KKW, Hayes RL, Pineda J: Alpha-II-Spectrin After Controlled Cortical Impact In The Immature Rat Brain: Dev Neurosci. 2006;28(4-5):457-65.
  12. Pineda JA, Lewis SB, Valadka AB, Papa L, Hannay HJ, Heaton SC, Demery JA, Liu MC, Aikman JM, Akle V, Brophy GM, Tepas JJ, Wang KK, Robertson CS, Hayes RL: Clinical significance of Alpha-II-Spectrin Breakdown Products in CSF after Severe Traumatic Brain Injury. J Neurotrauma. 2007 Feb;24(2):354-66.
  13. Germanò A, Caffo M, Angileri FF, Arcadi F, Newcomb-Fernandez J, Caruso G, Meli F, Pineda JA, Lewis SB, Wang KK, Bramanti P, Costa C, Hayes RL. NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat. J Neurotrauma. 2007 Apr; 24(4):732-44.
  14. Lewis SB, Velat GJ, Miralia L, Papa L, Aikman JM, Wolper RA, Firment CS, Liu MC, Pineda JA, Wang KK, Hayes RL.Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury. J Neurosurg. 2007 Oct;107(4):792-6.
  15. Dean NP, Boslaugh S, Adelson PD, Pineda JA, Leonard JR. Physician agreement with evidence-based recommendations for the treatment of severe traumatic brain injury in children. J Neurosurg. 2007 Nov;107(5):387-391.
  16. Leonard J, Leonard J, Ray WZ, Pineda JA. Traumatic brain injury in children. Mo Med. 2008 Sep-Oct;105(5):404-11; quiz 411-2.
  17. Brophy GM, Pineda JA, Papa L, Lewis SB, Valadka AB, Hannay HJ, Heaton SC, Demery JA, Liu MC, Tepas JJ, Gabrielli A, Robicsek S, Wang KK, Robertson CS, Hayes RL. AlphaII-Spectrin Breakdown Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms after Severe Traumatic Brain Injury.J Neurotrauma. 2009 Feb 10. [Epub ahead of print] 

Invited Publications:

1.     Pineda, JA, Book Review: Traumatic Head Injury in Children. Archives of Pediatrics & Adolescent Medicine. 1997; 151(12):1271

2.     Pineda JA: The Future of Traumatic Brain Injury: How Will It Fit Children. Brain Injury Source. Winter 2002; 6(1): 28-30

3.     Pineda JA, Zaritsky AL: The relationship of oxygen consumption to cerebral functional activity. The Journal of Pediatrics 2004; 144(1): 29

4.     Pineda JA, Wang KWW, Hayes RL: Biomarkers Of Proteolytic Damage Following Traumatic Brain Injury. Brain Pathology 2004; 14(2): 202-9

5.     Pineda JA, Tepas JJ: Caring for the child with severe traumatic brain injury: Old lessons learned and new concepts (Editorial). Pediatr Crit Care Med. 2006 Sep;7(5):496-7.

 

 

 

  1. Nellgard B, Mackensen GB, Pineda J, Wellons JC, Pearlstein RD, Warner DS: Anesthetic Effects on Cerebral Metabolic Rate Predict Histologic Outcome from Near-complete Forebrain Ischemia in the Rat. Anesthesiology. 93(2):431-436, August 2000.
  2.  Pineda JA, Aono M, Sheng H, Lynch J, Wellons JC, Laskowitz DT, Pearlstein RD, Bowler R, Crapo J, Warner DS: Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse. J Neurotrauma. 2001 Jun;18(6):625-34.
  3. Lynch JR, Pineda JA, Morgan D, Zhang L, Warner DS, Benveniste H, Laskowitz DT: Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol. 2002 Jan;51(1):113-7.
  4. Mackensen GB, Sato Y, Nellgard B, Pineda J, Newman MF, Warner DS, Grocott HP: Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 2001 Dec;95(6):1485-91.
  5. Modell JH, Idris AH, Pineda JA, Silverstein JH: Survival after prolonged submersion in freshwater in Florida. Chest; 125(5): 1948-51, May 2004.
  6. Wainwright MS, Craft JM, Griffin WS, Marks A, Pineda J, Padgett K, Van Eldik L: Increased Susceptibility of S100B Transgenic Mice to Perinatal Hypoxia-Ischemia. Ann Neurol. 2004 Jul;56(1):61-7.
  7. Johnson E, Pike BR, Tolentino P, Shaw G, Kampfl A, Wang KWW, Hayes RL, Pineda JA: Up-regulation of the Cell Cycle Protein, Survivin, in Astrocytes and Neurons After Experimental Traumatic Brain Injury in Rats. J Neurotrauma. 2004 Sep; 21(9):1183-95.
  8. Ringger NC, O'Steen BE, Brabham JG, Silver X, Pineda J, Wang KKW, Hayes RL, Papa L: A Novel Marker for Traumatic Brain Injury: CSF II-Spectrin Breakdown Product Levels. J Neurotrauma. 2004 Oct; 21(10): 1443-56.
  9. WE. Haskins, FH. Kobeissy, RA. Wolper, AK Ottens, JW Kitlen, MC Liu, SH McClung, AG Lundberg, Barbara E. O'Steen, Marjorie M. Chow, JA Pineda, Nancy D. Denslow, Ronald L. Hayes, Kevin K.W. Wang. Rapid Discovery of Putative Protein Biomarkers of Traumatic Brain Injury by SDS-PAGE-Capillary Liquid Chromatography-Tandem Mass Spectrometry. J Neurotrauma. 2005 Jun;22(6):629-44.
  10. Erik A. Johnson, Stanislav I. Svetlov, Kevin K.W. Wang, Ronald L. Hayes, JA Pineda: Cell-specific DNA Fragmentation May Be Attenuated by a Survivin-dependent Mechanism Following Traumatic Brain Injury in Rats. Exp Brain Res. 2005 Nov;167(1):17-26.
  11. Aikman JM, Osteen BE, Silver X, Torres R, Boslaugh S, Blackband S, Padgett K, Wang KKW, Hayes RL, Pineda J: Alpha-II-Spectrin After Controlled Cortical Impact In The Immature Rat Brain: Dev Neurosci. 2006;28(4-5):457-65.
  12. Pineda JA, Lewis SB, Valadka AB, Papa L, Hannay HJ, Heaton SC, Demery JA, Liu MC, Aikman JM, Akle V, Brophy GM, Tepas JJ, Wang KK, Robertson CS, Hayes RL: Clinical significance of Alpha-II-Spectrin Breakdown Products in CSF after Severe Traumatic Brain Injury. J Neurotrauma. 2007 Feb;24(2):354-66.
  13. Germanò A, Caffo M, Angileri FF, Arcadi F, Newcomb-Fernandez J, Caruso G, Meli F, Pineda JA, Lewis SB, Wang KK, Bramanti P, Costa C, Hayes RL. NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat. J Neurotrauma. 2007 Apr; 24(4):732-44.
  14. Lewis SB, Velat GJ, Miralia L, Papa L, Aikman JM, Wolper RA, Firment CS, Liu MC, Pineda JA, Wang KK, Hayes RL.Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury. J Neurosurg. 2007 Oct;107(4):792-6.
  15. Dean NP, Boslaugh S, Adelson PD, Pineda JA, Leonard JR. Physician agreement with evidence-based recommendations for the treatment of severe traumatic brain injury in children. J Neurosurg. 2007 Nov;107(5):387-391.
  16. Leonard J, Leonard J, Ray WZ, Pineda JA. Traumatic brain injury in children. Mo Med. 2008 Sep-Oct;105(5):404-11; quiz 411-2.
  17. Brophy GM, Pineda JA, Papa L, Lewis SB, Valadka AB, Hannay HJ, Heaton SC, Demery JA, Liu MC, Tepas JJ, Gabrielli A, Robicsek S, Wang KK, Robertson CS, Hayes RL. AlphaII-Spectrin Breakdown Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms after Severe Traumatic Brain Injury.J Neurotrauma. 2009 Feb 10. [Epub ahead of print] 

Invited Publications:

1.     Pineda, JA, Book Review: Traumatic Head Injury in Children. Archives of Pediatrics & Adolescent Medicine. 1997; 151(12):1271

2.     Pineda JA: The Future of Traumatic Brain Injury: How Will It Fit Children. Brain Injury Source. Winter 2002; 6(1): 28-30

3.     Pineda JA, Zaritsky AL: The relationship of oxygen consumption to cerebral functional activity. The Journal of Pediatrics 2004; 144(1): 29

4.     Pineda JA, Wang KWW, Hayes RL: Biomarkers Of Proteolytic Damage Following Traumatic Brain Injury. Brain Pathology 2004; 14(2): 202-9

5.     Pineda JA, Tepas JJ: Caring for the child with severe traumatic brain injury: Old lessons learned and new concepts (Editorial). Pediatr Crit Care Med. 2006 Sep;7(5):496-7.

 

 

 
 
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