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Faculty Bio

Patrick Y. Jay, M.D., Ph.D.

Assistant Professor of Pediatrics

Cardiology
Developmental Biology and Genetics

 

Patrick Y. Jay, M.D., Ph.D.

Assistant Professor of Pediatrics

Cardiology
Developmental Biology and Genetics

 

Education
  • B.S., Stanford University, 1987
  • M.D., Ph.D., Washington University School of Medicine, 1995
  • B.S., Stanford University, 1987
  • M.D., Ph.D., Washington University School of Medicine, 1995
Training
  • Resident, Children's Hospital, Boston, Massachusetts, 1995-97
  • Fellowship in Cardiology, Children's Hospital, Boston, Massachusetts 1997-2001
  • Resident, Children's Hospital, Boston, Massachusetts, 1995-97
  • Fellowship in Cardiology, Children's Hospital, Boston, Massachusetts 1997-2001
Licensure and Board Certification
  • Missouri License, 2004
  • American Board of Pediatrics, sub-board Pediatric Cardiology, 2002
  • Missouri License, 2004
  • American Board of Pediatrics, sub-board Pediatric Cardiology, 2002
Honors
  • Richard D. Rowe Award in Perinatal Cardiology, 2004
  • Chancellor's Hartwell Prize for Innovative Research, 2005
  • Richard D. Rowe Award in Perinatal Cardiology, 2004
  • Chancellor's Hartwell Prize for Innovative Research, 2005
Selected Publications
  • Jay PY, Harris BS, Maguire CT, Buerger A, Wakimoto H, Tanaka M, Kupershmidt S, Roden DM, Schultheiss TM, O’Brien TX, Gourdie RG, Berul CI, Izumo S. Nkx2-5 Mutation Causes Anatomic Hypoplasia of the Cardiac Conduction System. J Clin Invest.  113:1130-1137 (2004).
  • Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, Abel ED, Pu WT, Izumo S, Jay PY. Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail.  12:392-398 (2006).
  • Jay PY, Bielinska M, Erlich JM, Mannisto S, Pu WT, Heikinheimo M, Wilson DB. Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol.  301:602-614 (2007).
  • McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, Hewitt KA, Mollica JP, Zhang L, Zhang Y, Sherwood MC, Shioi T, Buerger A, Izumo S, Jay PY, Jennings GL. Protective effects of exercise and PI3K(p110a) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci USA.  104:612-617 (2007).
  • Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY, Milbrandt J. Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development  134:3191-3201 (2007).
  • Hruz PW, Yan Q, Struthers HM, Jay PY. HIV Protease Inhibitors that Block GLUT4 Precipitate Decompensated Heart Failure in a Model of Dilated Cardiomyopathy. FASEB J. 22:2161-2167 (2008).
  • Jay PY, Harris BS, Maguire CT, Buerger A, Wakimoto H, Tanaka M, Kupershmidt S, Roden DM, Schultheiss TM, O’Brien TX, Gourdie RG, Berul CI, Izumo S. Nkx2-5 Mutation Causes Anatomic Hypoplasia of the Cardiac Conduction System. J Clin Invest.  113:1130-1137 (2004).
  • Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, Abel ED, Pu WT, Izumo S, Jay PY. Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail.  12:392-398 (2006).
  • Jay PY, Bielinska M, Erlich JM, Mannisto S, Pu WT, Heikinheimo M, Wilson DB. Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol.  301:602-614 (2007).
  • McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, Hewitt KA, Mollica JP, Zhang L, Zhang Y, Sherwood MC, Shioi T, Buerger A, Izumo S, Jay PY, Jennings GL. Protective effects of exercise and PI3K(p110a) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci USA.  104:612-617 (2007).
  • Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY, Milbrandt J. Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development  134:3191-3201 (2007).
  • Hruz PW, Yan Q, Struthers HM, Jay PY. HIV Protease Inhibitors that Block GLUT4 Precipitate Decompensated Heart Failure in a Model of Dilated Cardiomyopathy. FASEB J. 22:2161-2167 (2008).
 
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