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Thomas Ferkol, M.D.
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Professor of Pediatrics, Cell Biology and Physiology
Director, Pediatric Pulmonology Fellowship Program
Director, Division of Allergy, Immunology and Pulmonary Medicine
Director, Cystic Fibrosis Center
Cystic Fibrosis Center
Allergy, Immunology and Pulmonary Medicine
Patient Oriented Research
Dr. Ferkol graduated from Case Western Reserve University (Cleveland, Ohio) in 1981, and he received his M.D. degree from the Ohio State University College of Medicine (Columbus, Ohio) in 1985. He was a pediatric resident at the University of North Carolina at Chapel Hill (1985-1988), where he also served as Chief Resident and Clinical Instructor (1988-1989). Dr. Ferkol returned to Case Western Reserve University in 1989 for fellowship training in pediatric pulmonology, and subsequently joined the pediatric faculty of Case Western Reserve University and Rainbow Babies and Children’s Hospital (Instructor in 1992-1994, and Assistant Professor 1994-2000).
Dr. Ferkol moved to Washington University School of Medicine in 2000, where he currently is Professor of Pediatrics, Cell Biology and Physiology and Director of the Division of Pediatric Allergy, Immunology, and Pulmonary Medicine. In addition, he serves as the Director of the Pediatric Pulmonology Fellowship Training Program at Washington University School of Medicine and St. Louis Children’s Hospital, and Director of the comprehensive, accredited Washington University Cystic Fibrosis Center, which supports premier clinical and research programs in cystic fibrosis. The Center is a member of the Cystic Fibrosis Foundation Therapeutics Development Network.
An American Lung Association Edward Livingston Trudeau Scholar and recipient of the Cystic Fibrosis Foundation LeRoy Matthew’s Physician-Scientist Award, Dr. Ferkol’s research has focused on the development of cell and animal models to study cystic fibrosis, defining genetic and molecular factors that contribute to chronic endobronchial infection, inflammation, and airway injury. With funding from the National Institutes of Health and Cystic Fibrosis Foundation, he and his collaborators have developed novel approaches for airway-specific drug delivery and non-invasive measures of inflammation in the cystic fibrosis lung. These approaches will provide better assessment tools and novel treatment strategies for suppurative lung diseases in children.
More recently, his laboratory has turned its research focus to another airway disease, primary ciliary dyskinesia, a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Ferkol serves as an investigator for the National Institutes of Health-supported Genetic Diseases of Mucociliary Clearance Consortium, a clinical research network to study rare diseases of the airways, concentrating on primary ciliary dyskinesia and variant forms of cystic fibrosis. He has also created a multidisciplinary research collaborative that will coordinate clinical characterization, identify functional and ultrastructural defects, and perform genetic testing of patient subpopulations with known or suspected ciliopathies, a project funded by the Children’s Discovery Institute. Dr. Ferkol has assembled clinical and scientific expertise from across both university campuses that are studying the genetic and phenotypic spectrum of ciliopathies, which should lead to improved standards for diagnosis, clinical care, and identification of novel therapeutic approaches.
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Thomas Ferkol, M.D.
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Professor of Pediatrics, Cell Biology and Physiology
Director, Pediatric Pulmonology Fellowship Program
Director, Division of Allergy, Immunology and Pulmonary Medicine
Director, Cystic Fibrosis Center
Cystic Fibrosis Center
Allergy, Immunology and Pulmonary Medicine
Patient Oriented Research
Dr. Ferkol graduated from Case Western Reserve University (Cleveland, Ohio) in 1981, and he received his M.D. degree from the Ohio State University College of Medicine (Columbus, Ohio) in 1985. He was a pediatric resident at the University of North Carolina at Chapel Hill (1985-1988), where he also served as Chief Resident and Clinical Instructor (1988-1989). Dr. Ferkol returned to Case Western Reserve University in 1989 for fellowship training in pediatric pulmonology, and subsequently joined the pediatric faculty of Case Western Reserve University and Rainbow Babies and Children’s Hospital (Instructor in 1992-1994, and Assistant Professor 1994-2000).
Dr. Ferkol moved to Washington University School of Medicine in 2000, where he currently is Professor of Pediatrics, Cell Biology and Physiology and Director of the Division of Pediatric Allergy, Immunology, and Pulmonary Medicine. In addition, he serves as the Director of the Pediatric Pulmonology Fellowship Training Program at Washington University School of Medicine and St. Louis Children’s Hospital, and Director of the comprehensive, accredited Washington University Cystic Fibrosis Center, which supports premier clinical and research programs in cystic fibrosis. The Center is a member of the Cystic Fibrosis Foundation Therapeutics Development Network.
An American Lung Association Edward Livingston Trudeau Scholar and recipient of the Cystic Fibrosis Foundation LeRoy Matthew’s Physician-Scientist Award, Dr. Ferkol’s research has focused on the development of cell and animal models to study cystic fibrosis, defining genetic and molecular factors that contribute to chronic endobronchial infection, inflammation, and airway injury. With funding from the National Institutes of Health and Cystic Fibrosis Foundation, he and his collaborators have developed novel approaches for airway-specific drug delivery and non-invasive measures of inflammation in the cystic fibrosis lung. These approaches will provide better assessment tools and novel treatment strategies for suppurative lung diseases in children.
More recently, his laboratory has turned its research focus to another airway disease, primary ciliary dyskinesia, a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Ferkol serves as an investigator for the National Institutes of Health-supported Genetic Diseases of Mucociliary Clearance Consortium, a clinical research network to study rare diseases of the airways, concentrating on primary ciliary dyskinesia and variant forms of cystic fibrosis. He has also created a multidisciplinary research collaborative that will coordinate clinical characterization, identify functional and ultrastructural defects, and perform genetic testing of patient subpopulations with known or suspected ciliopathies, a project funded by the Children’s Discovery Institute. Dr. Ferkol has assembled clinical and scientific expertise from across both university campuses that are studying the genetic and phenotypic spectrum of ciliopathies, which should lead to improved standards for diagnosis, clinical care, and identification of novel therapeutic approaches.
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- B.A., Case Western Reserve University, Ohio, 1981
- M.D., The Ohio State University College of Medicine, 1985
- B.A., Case Western Reserve University, Ohio, 1981
- M.D., The Ohio State University College of Medicine, 1985
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- Residency, Department of Pediatrics, North Carolina Memorial Hospital, University of North Carolina at Chapel Hill (1985-1988)
- Chief Resident, Department of Pediatrics, North Carolina Memorial Hospital, College of Medicine, University of North Carolina at Chapel Hill (1988-1989)
- Pulmonology Fellow, Division of Pediatric Pulmonology, Rainbow Babies and Children’s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio (1989-1992)
- Residency, Department of Pediatrics, North Carolina Memorial Hospital, University of North Carolina at Chapel Hill (1985-1988)
- Chief Resident, Department of Pediatrics, North Carolina Memorial Hospital, College of Medicine, University of North Carolina at Chapel Hill (1988-1989)
- Pulmonology Fellow, Division of Pediatric Pulmonology, Rainbow Babies and Children’s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio (1989-1992)
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- Floyd Denny Pediatric Alumni Society Award, University of North Carolina at Chapel Hill
- Cystic Fibrosis Foundation LeRoy Matthews Physician-Scientist Award
- American Lung Association Edward Livingston Trudeau Scholar
- Teaching Excellence Award, Case Western Reserve University School of Medicine
- Member, Society for Pediatric Research
- EDI Innovation Award
- European Cystic Fibrosis Conference Award
- Best Doctors of America
Scientific Review Committees
- National Institutes of Health, Gene and Drug Delivery (GDD) study section (2003-2005, 2008)
- American Thoracic Society Career Development Grants Review Committee (2007-2008)
- Cystic Fibrosis Foundation Research Development Program (RDP) Review Committee, ad hoc
- Cystic Fibrosis Foundation Functional Genomics Review Committee, ad hoc
Medical Societies and Committees
- American Thoracic Society Pediatric Assembly Program Committee Chair-elect (2006-2007)
- American Thoracic Society Pediatric Assembly Program Committee Chair (2007-2008)
- American Thoracic Society Pediatric Assembly Chair-elect (2008-2009)
- American Thoracic Society Pediatric Assembly Chair (2009-2011)
- American Thoracic Society Health Policy Committee (2008-2009)
- American Thoracic Society Board of Directors (2009-2011)
- American Board of Pediatrics, Subboard of Pediatric Pulmonology (2011-2016)
- Society for Pediatric Research (1997-present)
- Co-director, Cystic Fibrosis Foundation Therapeutics Development Center, Washington University School of Medicine (2003-2007)
- Program Planning Committee, North American Cystic Fibrosis Conference (2006-2007)
- Cystic Fibrosis Foundation Newborn Screening Special Interest Group (2006-present)
- Medical Advisor, Gateway Chapter, Cystic Fibrosis Foundation (2000-present)
- State of Missouri Neonatal Screening Standing Committee (2004-present)
- Pediatric Pulmonary Training Directors Association (PEPTDA) Chair (2007-2009)
- Association of Pediatric Program Directors
- Floyd Denny Pediatric Alumni Society Award, University of North Carolina at Chapel Hill
- Cystic Fibrosis Foundation LeRoy Matthews Physician-Scientist Award
- American Lung Association Edward Livingston Trudeau Scholar
- Teaching Excellence Award, Case Western Reserve University School of Medicine
- Member, Society for Pediatric Research
- EDI Innovation Award
- European Cystic Fibrosis Conference Award
- Best Doctors of America
Scientific Review Committees
- National Institutes of Health, Gene and Drug Delivery (GDD) study section (2003-2005, 2008)
- American Thoracic Society Career Development Grants Review Committee (2007-2008)
- Cystic Fibrosis Foundation Research Development Program (RDP) Review Committee, ad hoc
- Cystic Fibrosis Foundation Functional Genomics Review Committee, ad hoc
Medical Societies and Committees
- American Thoracic Society Pediatric Assembly Program Committee Chair-elect (2006-2007)
- American Thoracic Society Pediatric Assembly Program Committee Chair (2007-2008)
- American Thoracic Society Pediatric Assembly Chair-elect (2008-2009)
- American Thoracic Society Pediatric Assembly Chair (2009-2011)
- American Thoracic Society Health Policy Committee (2008-2009)
- American Thoracic Society Board of Directors (2009-2011)
- American Board of Pediatrics, Subboard of Pediatric Pulmonology (2011-2016)
- Society for Pediatric Research (1997-present)
- Co-director, Cystic Fibrosis Foundation Therapeutics Development Center, Washington University School of Medicine (2003-2007)
- Program Planning Committee, North American Cystic Fibrosis Conference (2006-2007)
- Cystic Fibrosis Foundation Newborn Screening Special Interest Group (2006-present)
- Medical Advisor, Gateway Chapter, Cystic Fibrosis Foundation (2000-present)
- State of Missouri Neonatal Screening Standing Committee (2004-present)
- Pediatric Pulmonary Training Directors Association (PEPTDA) Chair (2007-2009)
- Association of Pediatric Program Directors
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Joseph T, Look DC, Ferkol TW. NF-kB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol 288:L471-9;2005.
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Chen DL, Ferkol TW, Mintun MA, Pittman J, Wilson, K Rosenbluth DB, Schuster DP. Quantifying pulmonary inflammation in cystic fibrosis with positron emission tomography. Am J Respir Crit Care Med 173:1363-9;2006.
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Gregory AD, Hogue LA, Ferkol TW, Link DC. Regulation of systemic and local neutrophil responses by GCSF during pulmonary bacterial infection. Blood 109:3235-43;2007.
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Sedor J, Hogue L, Akers K, Schreiber J, Ferkol T. Altered clearance of Pseudomonas aeruginosa from lungs of mice deficient in cathepsin-G. Pediatr Res 61:26-31;2007.
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Leigh MW, Pittman JE, Carson JL, Ferkol TW, Dell SD, Davis SD, Knowles MR, Zariwala MA. Clinical and genetic aspects of primary ciliary dyskinesia. Genet Med. 11:473-87;2009.
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Chen DL, Bedient TJ, Kozlowski J, Rosenbluth DB, Isakow W, Ferkol TW, Thomas B, Mintun MA, Schuster DP, Walter MJ. [18F]fluorodeoxyglucose positron emission tomography for lung antiinflammatory response evaluation. Am J Respir Crit Care Med. 180:533-9;2009.
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Farberman MM, Akers KT, Townsend RR, Ferkol TW. Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis. Eur Respir J. 2010. In press.
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Joseph T, Look DC, Ferkol TW. NF-kB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol 288:L471-9;2005.
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Chen DL, Ferkol TW, Mintun MA, Pittman J, Wilson, K Rosenbluth DB, Schuster DP. Quantifying pulmonary inflammation in cystic fibrosis with positron emission tomography. Am J Respir Crit Care Med 173:1363-9;2006.
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Gregory AD, Hogue LA, Ferkol TW, Link DC. Regulation of systemic and local neutrophil responses by GCSF during pulmonary bacterial infection. Blood 109:3235-43;2007.
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Sedor J, Hogue L, Akers K, Schreiber J, Ferkol T. Altered clearance of Pseudomonas aeruginosa from lungs of mice deficient in cathepsin-G. Pediatr Res 61:26-31;2007.
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Leigh MW, Pittman JE, Carson JL, Ferkol TW, Dell SD, Davis SD, Knowles MR, Zariwala MA. Clinical and genetic aspects of primary ciliary dyskinesia. Genet Med. 11:473-87;2009.
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Chen DL, Bedient TJ, Kozlowski J, Rosenbluth DB, Isakow W, Ferkol TW, Thomas B, Mintun MA, Schuster DP, Walter MJ. [18F]fluorodeoxyglucose positron emission tomography for lung antiinflammatory response evaluation. Am J Respir Crit Care Med. 180:533-9;2009.
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Farberman MM, Akers KT, Townsend RR, Ferkol TW. Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis. Eur Respir J. 2010. In press.
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Ferkol T, Rosenfeld M, and Milla CE. Cystic fibrosis pulmonary exacerbations. J Pediatr 148:259-64;2006.
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Lie H, Ferkol T. Primary ciliary dyskinesia: recent advances in pathogenesis, diagnosis and treatment. Drugs 67:1883-92;2007.
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Elizur A, Cannon C, Ferkol T. Inflammation in the cystic fibrosis lung. Chest. 133:489-95;2008.
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Ferkol T, Zeitlin P, Abman S, Blaisdell CJ, O’Brodovich H. NHLBI Training Workshop report: the vanishing pediatric pulmonary investigator and recommendations for recovery. Lung. 2009. In press.
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Ferkol T. Primary ciliary dyskinesia. In Behrman RE, Kliegman RM, Jenson HB, eds. Nelson’s Textbook of Pediatics. Philadelphia, PA: Elsevier Health Sciences. 2010. In press.
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Ferkol T, Rosenfeld M, and Milla CE. Cystic fibrosis pulmonary exacerbations. J Pediatr 148:259-64;2006.
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Lie H, Ferkol T. Primary ciliary dyskinesia: recent advances in pathogenesis, diagnosis and treatment. Drugs 67:1883-92;2007.
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Elizur A, Cannon C, Ferkol T. Inflammation in the cystic fibrosis lung. Chest. 133:489-95;2008.
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Ferkol T, Zeitlin P, Abman S, Blaisdell CJ, O’Brodovich H. NHLBI Training Workshop report: the vanishing pediatric pulmonary investigator and recommendations for recovery. Lung. 2009. In press.
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Ferkol T. Primary ciliary dyskinesia. In Behrman RE, Kliegman RM, Jenson HB, eds. Nelson’s Textbook of Pediatics. Philadelphia, PA: Elsevier Health Sciences. 2010. In press.
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