School of Medicine Header
WUSTL.EDU
Department of Pediatrics Header
  Pediatrics Home Divisions / Faculty Research Residency / Fellowships Education
Faculty Bio

Todd Druley, M.D., Ph.D.

Assistant Professor in Pediatrics and Genetics

Hematology/Oncology

Dr. Druley is a faculty member in the Division of Pediatric Hematology and Oncology.  His research is based in the hypothesis that much of pediatric disease presentation and treatment is heavily influenced by the unique combination of rare inherited DNA mutations within each person. Dr. Druley’s research focuses on adapting the latest genomic technologies toward characterizing these germline variants on a population-based scale as well as examining how these mutations interact within an individual to influence a variety of diseases, particularly pediatric cancer. The long-term goals are to better understand the pathophysiology of pediatric cancer as well as to identify all of the pertinent germline variants within a pediatric cancer patient prior to starting therapy in order to provide a genetically customized treatment plan designed to maximize anti-cancer activity while minimizing toxicity and morbidity.
Education
  • B.S., University of Illinois at Urbana-Champaign, 1990-1994
  • M.D./Ph.D. Training Program, University of Illinois at Chicago, 1994-2002

 
Training
  • Intern in Pediatrics, St. Louis Children's Hospital, 2002-2003
  • Resident in Pediatrics, St. Louis Children's Hospital, 2003-2005  
  • Fellow in Pediatric Hematology and Oncology, Washington University, 2005-2008

 
Licensure and Board Certification
  • Missouri License, 2008
  • American Board of Pediatrics, 2006
  • Pediatric Hematology and Oncology, eligible

 
Honors
  • Faculty Scholar of the Children's Discovery Institute, 2010-present
  • Mark Johnston Scholar in the Genomic Sciences, 2009-present
  • Eli Seth Matthews Leukemia Foundation Award Recipient, 2010-present
  • Alex's Lemonade Stand "A" Award, 2009-2012
  • Hyundai Hope on Wheels Scholar in Pediatric Oncology, 2009
  • Scholar of the NIH Child Health Research Center in Developmental Biology, 2009-present
  • Member, Siteman Cancer Center, NIH Comprehensive Cancer Center, 2008-present
  • Outstanding Fellow Teaching Award, 2005-2006
  • University Distinction for Research in Cell and Structural Biology, 1994, University of Illinois at Urbana-Champaign
  • Children of Vietnam Veterans Merit Scholarship, 1990-1994, University of Illinois at Urbana-Champaign

 
Selected Publications
  1. Chatterjee R, Ramos E, Hoffman M, VanWinkle J, Martin D, Davis TK, Hoshi M, Hmiel SP, Beck A, Hruska K, Coplen D, Liapis H, Mitra R, Druley T, Austin P, Jain S. Traditional and targeted exome sequencing reveals common, rare and novel deleterious variants in RET signaling complex in a cohort of living US patients with urinary tract malformations. Hum Genet. DOI 10.1007/s00439-012-1181-3, 2012.
  2. Vallania FLM, Ramos E, Cresci S, Mitra RD, Druley TE. Detection of rare genomic variants from pooled sequencing using SPLINTER. J. of Visualized Experiments. 64: e3943, DOI 10.3791/3943, 2012.
  3. Haller G, Druley T, Vallania FL, Mitra RD, Li P, Akk G, Steinbach JH, Breslau N, Johnson E, Hatsukami D, Stitzel J, Bierut L, Goate A. Rare missense variants in CHRNB4 reduce risk of nicotine dependence. Hum Mol Genet 21: 647-655, 2012.
  4. Vallania FLM, Druley TE, Ramos E, Wang J, Borecki I, Province M, Mitra RD. High-throughput discovery of rare insertions and deletions in large cohorts. Genome Res 20: 1711-1718; 2010.
  5. Ziga ED, Druley T, Burnham CA. Herbaspirillum species bacteremia in a pediatric oncology patient. J Clin Microbiol 48(11): 4320-4321, 2010.
  6. Gurnett CA, Desruisseau DM, McCall K, Choi R, Meyer Zl, Talerico M, Miller SE, Ju JS, Pestronk A, Connolly AM, Druley TE, Weihl CC, Dobbs MB. Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1. Hum Mol Genet 19: 1165-1173, 2010.
  7. Matkovich SJ, Van Booven DJ, Hindes A, Young Kang M, Druley TE, Vallania FLM, Mitra RD, Reilly MP, Cappola TP, Dorn GW.  Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease.  J Clin Invest 120: 280-289, 2010.
  8. Schuettpelz LG, Behrens D, Goldsmith MI, Druley TE. Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease. J Pediatr Hematol Oncol 31: 870-872, 2009.
  9. Druley TE, Vallania FL, Wegner DJ, Varley KE, Knowles OL, Bonds JA, Robison SW, Doniger SW, Hamvas A, Cole FS, Fay JC and Mitra RD. Quantification of rare allelic variants from pooled genomic DNA. Nature Methods 6: 263-265, 2009.
  10. Druley TE, Hayashi R, Mansur DB, Zhang QJ, Barnes Y, Trinkaus K, Witty S, Thomas T, Klein EE, DiPersio JF, Adkins D and Shenoy S. Early outcomes after allogeneic hematopoietic SCT in pediatric patients with hematologic malignancies following single fraction TBI. Bone Marrow Transplantation 43: 307-314, 2009.
  11. Druley TE, Stein WD and Roninson IB. Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity. Biochemistry 40: 4312-4322, 2001.       
  12. Druley TE, Stein WD, Ruth A and Roninson IB. P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation.  Biochemistry 40: 4323-4331, 2001.
  13. Litman T, Druley TE, Stein WD and Bates S. From MDR to MXR: New understandings of the multidrug resistance systems, their properties and clinical significance.  Cell. Mol. Life Sci. 58: 931-959, 2001.
  14. Mechetner EB, Schott B, Morse BS, Stein WD, Druley T, Davis KA, Tsuruo T and Roninson IB. P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity. PNAS 94: 12908-12913, 1997.
Shield
Medical School URL