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David B. Wilson, M.D., Ph.D.
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Associate Professor of Pediatrics and Developmental Biology
Attending physician in Hematology/Oncology
Hematology and Oncology
Developmental Biology and Genetics
Dr. Wilson's laboratory studies the role of transcription factors in differentiation and development. This work centers on the GATA-binding proteins, a group of zinc finger transcription factors implicated in lineage commitment. Techniques employed in the laboratory include homologous recombination in embryonic stem cells, transgenic and chimeric mouse analyses, in situ hybridization, immunohistochemistry, DNA-binding studies, and trans-activation assays.
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- B.A., Kalamazoo College, 1980
- Ph.D., Washington University, 1986
- M.D., Washington University, 1986
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- Resident in Pediatrics, The Children's Hospital, Boston, 1987-1988
- Clinical Fellow in Pediatric Hematology/Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital, 1988-1989
- Research Fellow in Medicine (Hematology/Oncology), The Children's Hospital, Boston, and Harvard Medical School, 1989-1990
- Research Fellow in Pediatrics, Harvard Medical School, Boston, Ma., 1989-1990
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- Missouri License, 1992
- American Board of Pediatrics, 1993
- Pediatric Hematology-Oncology, 1996
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- McDonnell Scholars Award in Molecular Oncology, 1992
- Basil O'Connor Award from the March of Dimes, 1993-1995
- Established Investigator of American Heart Association, 1996-2000
- Elected to American Society for Clinical Investigation, 1998
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Bielinska M, Genova E, Boime I, Rahman N, Parvianinen H, Kiiveri S, Heikinheimo M, Wilson DB: Gonadotropin-induced adrenocortical neoplasia in NU/J nude mice. Endocrinol 2005; 146:3975-3984.
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Jacobsen CM, Mannisto S, Porter-Tinge S, Genova E, Parviainen H, Heikinheimo M, Adameyko II, Tevosian SG, and Wilson DB: GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev Dyn 2005; 234:355-362.
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Bielinska M, Kiiveri S, Parvianen H, Mannisto S, Heikinheimo M, and Wilson DB: Adrenocortical neoplasia in the domestic ferret (Mustela putorius furo) and laboratory mouse. Vet Pathol 2006; 43:97-117.
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Jay PY, Bielinska M, Erlich JM, Mannisto S, Pu WT, Heikinheimo M, Wilson DB: Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol 2007; 301:602-614..
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Bielinska M, Seehra A, Toppari J, Heikinheimo M, Wilson DB: GATA-4 is required for sex steroidogenic cell development in the fetal mouse. Dev Dyn 2007; 236:203-213.
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