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Joshua B. Rubin, M.D., Ph.D.
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Assistant Professor of Pediatrics
Hematology and Oncology
Developmental Biology and Genetics
I am interested in the biology and treatment of pediatric brain tumors. In my laboratory we are using the model of normal central nervous system development to help identify molecules that regulate the movements, proliferation and survival of neural progenitor cells. We suspect that these same molecules will influence the infiltrative and metastatic behavior, as well as the proliferation and survival of brain cancer cells. Through this approach, we have identified two molecules, the chemokine CXCL12 (SDF-1a) and its receptor CXCR4 that are critical to normal cerebellar development and whose activation is necessary for growth of medulloblastoma, a neuronal tumor that is the most common brain tumor of childhood and glioblastoma multiforme, a malignant astrocytic tumor. These observations serve as the basis for a wide range of research regarding the role of CXCR4 in tumori-genesis in the CNS and the nature of the intracellular signals that support these functions. These observations also serve as the foundation for designing a clinical trial of CXCR4 antagonist therapy for brain tumors that we hope to have underway in the near future. This overlaps with my other research interest, which is in the clinical development of novel therapies for brain tumors. In the multidisciplinary Pediatric Brain Tumor Program here at St. Louis Children's Hospital, we are working to develop and deliver innovative therapies to children with brain tumors.
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- B.S., Yale University, 1982
- M.Sc., Albert Einstein College of Medicine, 1992
- Ph.D., Neuroscience, Albert Einstein College of Medicine, 1994
- M.D., Albert Einstein College of Medicine, 1994
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- Resident, Children's Hospital, Harvard University, Boston, Massachusetts, 1994-97
- Fellowship in Hematology/Oncology, Children's Hospital/Dana Farber Cancer Institute, Boston, Massachusetts, 1997-2000
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- Missouri License, 2004
- American Board of Pediatrics, sub-board Pediatric Hematology/Oncology, 2007
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- Alpha Omega Alpha, 1993
- NICHD Scholar of the Child Health Research Center for Excellence in developmental biology at Washington University School of Medicine, 2003-2006
- Hyundai Scholar, 2008
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- Rubin, J.B., & Gutmann, D.H. Neurofibromatosis type 1 - a model for nervous system tumour formation? Nature Cancer Reviews 5(7):557-564. (2005)
- Woerner, B.M., Warrington, N .M., Kung, A.L., Perry, A. & Rubin, J.B. (2005) Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-sepcific antibodies. Cancer Research 65(24) 11392-9.
- Yang, L, Jackson, E, Woerner, BM, Perry, A, Piwnica-Worms, D & Rubin, JB: Blocking CXCR4-mediated cAMP suppression inhibits brain tumor growth in vivo. (2007) Cancer Research. 67:651-8.
- Warrington, NM, Woerner, BM, Daginakatte, GC, Dasgupta, B, Perry, A, Gutmann, DH, Rubin, JB: Temporal regulation of CXCL12 expression may underlie the unique pattern of optic nerve glioma growth in NF1. (2007) Cancer Research. 67(18):8588-8595.
- Goldhoff P, Warrington, N, Limbrick, DD, Hope, A, Woerner, BM, Jackson, E, Perry, A, Piwnica-Worms, D, Rubin, JB. Targeted inhibition of phosphodiesterase type 4 promotes brain tumor regression. (2008) Clinical Cancer Research. In press.
- Hegedus, B, Banerjee, D, Yeh, T-H, Rothermich, S, Perry, A, Rubin, JB, Garbow, JR, Gutmann, DH. Preclinical Cancer Therapy in a Mouse Model of Neurofibromatosis-1 Optic Glioma. (2008) Cancer Research. 68: 1520-1528.
- Reilly, K., Rubin, J., Gilbertson, R., Garbow, J., Rousse;, M. & Gutmann, D. Re-thinking Brain Tumors: The Fourth Mouse Models of Human Cancer Consortium Nervous System Tumors Workshop. (2008) Cancer Research. 68(14):5508-5511.
- Kiehl, EL, Stojadinovic, S, Malinowski, KT, Limbrick, D, Jost, SC, Garbow, JR, Rubin, JB, Deasy, JO, Killan, D, Izaquirre, EW, Patikh, PJ, Low, DA, Hope, AJ. Feasibility of small animal crainial irradiation with the microRT system. (2008) Medical Physics. In press.
- Rubin, JB. Chemokine Signaling in Cancer: One Hump or Two?. Seminars in Cancer Biology. 2008. In press.
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